Acute ischemic stroke remains a devastating event. Only 1/3 of patiens recovers sufficiently to live independently. Why? Will you be the Ph.D. student who unravels part of the answer in translational research based on advanced stroke models and state of the art microscopy?
We are a dedicated research team at Amsterdam UMC, participating in the Dutch 'Collaboration for New Treatments of Acute Stroke' (CONTRAST) consortium. Our mission is to improve stroke treatment outcomes through in-depth investigations into the microcirculation of the brain. Supported by organizations like the Netherlands Heart Foundation and Netherlands Brain Foundation, our research seeks to unravel the complexities underlying post-thrombectomy microvascular dysfunction.
For years, patients with acute ischemic stroke have benefited from mechanical thrombectomy, a procedure that removes blood clots with catheters. However, many patients continue to experience inadequate recovery despite successful clot removal. We suspect that microvascular dysfunction in the brain, specifically among the smallest vessels, plays a significant role in post-thrombectomy complications.
As a Ph.D. student, you will explore the mechanisms behind microvascular dysfunction during stroke and post-thrombectomy conditions using experimental rodent stroke models.
- Investigate cellular and molecular processes within the microcirculation that contribute to impaired blood flow and oxygen delivery post-thrombectomy.
- Employ cutting-edge multiphoton imaging techniques with a cranial window setup to observe live brain microcirculation during stroke and reperfusion.
- Develop and implement data analysis strategies to extract valuable insights from extensive imaging datasets.
- Collaborate with our team to enhance our image analysis pipeline.
- Publish research findings in international scientific journals and present results at conferences.
- Mentor Bachelor's and Master's students during their research internships.
- Occasionally participate in teaching activities.