2 Postdoc positions 'Colloidal biomaterials for bone regeneration'

Infection and cancer often cause severe bone destruction, thereby dramatically reducing a person's health and quality of life. To treat these degenerative diseases, long-term systemic delivery of antibiotics or chemotherapeutics is still the gold standard. Unfortunately, systemic drug delivery causes severe side effects, whereas the effective drug concentration in diseased bone is often too low to reach an optimal effect. Therefore, biomaterials are increasingly used as carriers for local drug delivery. However, their therapeutic efficacy is poor due to their very invasive clinical application, their poor spatiotemporal control over drug delivery and their inability to deliver drugs directly into the interior of cells.

This project will design a new class of colloidal composite biomaterials which allow for i) minimally invasive delivery, ii) rapid bone regeneration even prior to biomaterial degradation, and iii) effective treatment of defects in infected or cancerous bone. These materials are both porous and self-healing due to their tunable self-assembly from submicron particles. State-of-the-art imaging techniques will be employed to correlate the porous and self-healing nature of colloidal biomaterials with their clinical handling and biological properties. These basic insights will be translated towards biomaterial-based solutions for unmet clinical needs in the treatment of diseased bone.

The postdoc positions are funded by a VICI grant "ColBioBone" of the Dutch Science Organization NWO. ColBioBone is actively supported by three companies with ample expertise in biomaterials and bone regeneration. One postdoc (background: materials science/colloidal materials) will synthesize a toolbox of colloidal building blocks to allow correlation of their physicochemical properties with the scaffold-like network architecture, self-healing capacity and clinical handling behavior of colloidal biomaterials. The other postdoc (background: cell biology) will investigate the fundamental relationship between the migration, proliferation and differentiation of cells invading colloidal biomaterials as a function of their porosity and self-healing capacity.

Tasks and responsibilities

• to synthesize and characterize organic and inorganic nanoparticles as building blocks for colloidal biomaterials.
• to investigate the fundamental relationship between the structure and functional properties of colloidal biomaterials.
• to investigate interactions between cells and self-healing colloidal biomaterials at a fundamental level.
• to supervise BSc, MSc and PhD students and disseminate the obtained knowledge by scientific publications and presentations at (inter)national conferences.
• to contribute to translation of basic research towards novel treatments for patients suffering from defects in diseased bone.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

The Postdoc candidate will be appointed at the department of Dentistry (research group Regenerative Biomaterials, Radboudumc, Nijmegen, The Netherlands) as part of a multidisciplinary team of researchers in- and outside Nijmegen consisting of polymer chemists, pharmacists, materials scientists, biologists, and dental and medical clinicians.

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