PhD Hematology, Oncology

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PhD Hematology, Oncology

PhD: Characterizing bone marrow-dependent drug resistance mechanisms in multiple myeloma We are looking for an ambitious PhD student for our project on the characterization of bone marrow-dependent signals that cause drug resistance in the hematologic...

Deadline 10 Apr ’23Published 27 Mar ’23 Vacancy ID 8297

Academic fields

Health

Job types

PhD

Education level

University graduate

Weekly hours

36 hours per week

Salary indication

€2789—€3536 per month

Location

Meibergdreef 9, 1105AZ, Amsterdam

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Job description

Multiple myeloma is a cancer that resides in the bone marrow and generally has a poor prognosis due to the development of drug resistance. The bone marrow microenvironment contributes to drug resistance by providing growth and survival factors that drive oncogenic signaling.

A better understanding of the interactions between multiple myeloma cells and the bone marrow microenvironment will provide new opportunities to improve therapy and prevent drug resistance.

About your role
In this project we will use functional genetic screens, innovative reporter assays and preclinical models to investigate the contribution of bone marrow-derived cues to oncogenic signaling and drug resistance in multiple myeloma cells.

We aim to unravel abnormal growth factor signaling in multiple myeloma to provide novel therapeutic targets and combination therapies.

Requirements

You are a highly motivated scientist with a master degree in biomedical sciences or a related field.

You are a team player, eager to learn and you have an analytical mindset.
Experience with cell culture, CRISPR/Cas9 screening and animal experimentation is preferred.
Article 9 permission to perform animal experiments is an advantage but not required.
Fluency in English (written and verbal) is required.

Conditions of employment

A challenging and varied job position in a dynamic and inspiring academic environment.
A PhD program that provides a unique opportunity to be involved in cutting edge science and to participate in national and international conferences.
A contract for 48 months.
OIO salary scale: € 2.789 tot € 3.536 gross at fulltime employment (depending on qualifications and expertise).
Additional benefits including an 8.3% end-of-year bonus and 8% holiday bonus.
Pension is accrued at BeFrank.
In addition to excellent accessibility by public transport, we reimburse 75% of your commuting costs. We have ample parking space at location AMC, and a bicycle reimbursement program.

Employer

Amsterdam UMC

The work is funded by a grant from the Koningin Wilhelmina Fonds (KWF) Dutch Cancer Society awarded to the research group headed by Dr. Jeroen Guikema at the Department of Pathology (Amsterdam UMC) at the Cancer Center Amsterdam, location AMC. The Guikema research group is part of the Lymphoma and Myeloma Center Amsterdam (LYMMCARE), which is a center of expertise for research, diagnostics and treatment of B-cell lymphoma and myeloma.

In this project we will collaborate closely with the Department of Hematology from the Amsterdam UMC, providing (pre-) clinical expertise. You will be embedded in the LYMMCARE research team of PhD students, postdoctoral fellows and research technicians that focuses on oncogenic signaling and microenvironmental factors in B-cell malignancies.

Together @ Amsterdam UMC

Amsterdam University Medical Center is a leading medical center that combines complex high-quality patient care, innovative scientific research and education of the next generation committed health care professionals. Together we discover the healthcare of tomorrow.