Postdoc Multilayer Networks in Neuro-oncology

Are you ready to help transform how we understand and treat oncological and neurological diseases? We are seeking an ambitious postdoctoral researcher to join a groundbreaking project that aims to bridge the biological scales of disease — from molecules to brain networks to cognition.

In neurodegenerative diseases, including Alzheimer’s Disease (AD), early molecular changes — such as dysregulation of key proteins — eventually lead to brain network disruptions and cognitive decline. However, connecting these dots across levels of biology remains one of the greatest challenges in modern neuroscience. Our project takes on this challenge head-on, using multilayer network theory: an exciting analytical framework that allows us to model, quantify, and understand interactions both within and between different biological scales.

You will work at the forefront of this innovation, building integrated network models that combine proteomic data (molecular scale) with brain network imaging (systems scale). Your goal is to identify the critical molecular and network targets that drive cognitive decline and, ultimately, to uncover new strategies for personalized therapeutic intervention.

This project sits at the intersection of computational neuroscience, systems biology, and clinical research. You will have access to rich multimodal datasets, including proteomic profiles and advanced neuroimaging from large Alzheimer’s cohorts, and will collaborate closely with a multidisciplinary team of neuroscientists, neurologists, and data scientists. While your primary focus will be on Alzheimer’s Disease, you will also have the opportunity to contribute to parallel projects targeting cognitive decline in multiple sclerosis and cancer, applying the multilayer network approach across different neurological and oncological populations.

If you are passionate about systems neuroscience, precision medicine, and innovative computational methods, and want to make a real impact on the future of research in this space, we would love to hear from you.

• A wonderful continuation of your career in scientific research.
• Plenty of room for your drive to shape tomorrow's healthcare.
• Working on large-scale and in-house research, with motivated colleagues from all over the world.
• You will be employed by Amsterdam UMC Research BV.
• A contract for 12 months, with the intention to extend for a total of 3 years.
• Salary scale 10: € 3.493 to € 5.504 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here. From July 1st, 2025, there will be a salary increase of 3%. Check out this article for more information on the improved employment conditions.
• Holiday hours: 190,4 per year for fulltime and a possibility to save additional hours.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
• For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
• Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

You will join the Multiscale Network Neuroscience (MULTINET) lab, where we aim to improve outcomes for glioma and other patients by understanding and manipulating personalized multiscale network data. Our multidisciplinary team focuses on three main goals: (1) embracing the complexity of brain networks by studying different populations with diverse methods; (2) integrating data across scales — from cells to brain networks to behavior — to uncover how local brain changes cause large-scale network disruptions in disease; and (3) predicting and treating clinical outcomes across brain tumors and other neurological or psychiatric conditions, focusing on shared symptoms like cognitive and physical impairments. We combine computational modeling, brain stimulation (TMS), and cellular experiments to reveal disease mechanisms and drive new treatments.

You are also part of the ADORE Biocomputational Focus group, which unites Amsterdam UMC biocomputational researchers who develop and apply computational methods relevant to onco- and neurological applications.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Watch the video to find out more.