Postdoc Cerebrale microcirculatie bij beroerte

For several years now, patients suffering from acute ischemic stroke have been treated with mechanical thrombectomy, where the blood clot is removed using a catheter. However, even after successful removal of the clot, blood flow to the brain often does not fully recover. Such incomplete reperfusion can lead to further infarct growth and contributes to the still poor outcomes in stroke patients.

In this project, we will investigate the vasculature during stroke and after thrombectomy to unravel the mechanisms involved in this incomplete reperfusion. We will also test new therapeutic interventions. To achieve this, we make use of animal models, cell cultures, and advanced microscopic imaging. The results of this project will help us to better understand the cerebral vasculature during stroke and recanalization therapy, and to identify potential new therapeutic strategies to improve treatment efficacy and patient outcomes.

A PhD student will also be appointed for this project Vacatures - PhD Cerebral microcirculation in stroke - Amsterdam UMC

You will investigate neurovascular processes and test new interventions aimed at reducing brain tissue damage after stroke. Using advanced in vivo microscopy and in vitro models, your work will include:

• Designing and conducting in vivo and in vitro stroke experiments;
• Improving microscopy protocols and solving technical & practical challenges;
• Analyzing large imaging datasets to understand microvascular behavior during and after stroke;
• Initiating grant applications to secure additional funding;
• Collaborating closely within an interdisciplinary research team.

You hold a PhD in neuroscience, cardiovascular sciences, or imaging.

In addition, you bring:

• Experience with animal research (including Article 9 certification or equivalent);
• Hands-on experience with in vivo models (such as MCAO) and in vitro systems (such as iPSC cultures, vessel-on-a-chip, or brain organoids);
• Proficiency in standard laboratory techniques, including qPCR, Western blot, ELISA, IHC, and confocal microscopy;
• Affinity with or experience in programming (Matlab/Python);
• Excellent command of English, both written and spoken.

• A flying start to your career in scientific research.
• Plenty of room for your drive to shape tomorrow's healthcare.
• Working on large-scale and in-house research, with motivated colleagues from all over the world.
• You will be employed by Amsterdam UMC Research BV.
• We offer a 2-3-year contract starting with 12 months, which will be extended to a maximum of 3 years after a yearly evaluation.
• Salary scale 10: € 3.598 to € 5.669 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here.
• Holiday hours: 190.4 per year for fulltime and a possibility to save additional hours.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
• For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
• Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

You will join the laboratory of Dr. Inge Mulder and Prof. Ed van Bavel within the Department of Biomedical Engineering & Physics at Amsterdam UMC, location AMC (and partly at VUmc when required). You will be part of an international research team focused on cerebral vasculature studies, both in vivo and in vitro. The group investigates stroke, large and microinfarcts, and employs cutting-edge technologies including two-photon imaging, MRI, ultrasound, and a self-developed imaging cryomicrotome.

Amsterdam UMC offers an inspiring, multidisciplinary, and collaborative research environment. You will receive excellent mentorship through innovative research projects, advanced courses, and training opportunities, complemented by workshops on research methods, transferable skills, and education.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Watch the video to find out more.