Technician Metabolomics

At Radboudumc, you will develop and optimize metabolomics methods to innovate diagnostics and therapy monitoring for rare metabolic and other genetic disorders.

You will be part of a recently established innovation team in our Department of Human Genetics, which has strong connections with laboratory specialists, researchers, and clinicians. The Functional Genomics subteam develops mass‑spectrometry‑based proteomics, glycoproteomics, and metabolomics methodologies for applications in patient care.

Your key responsibilities include:

• Developing and technically validating new, high‑resolution, mass‑spectrometry‑based LC‑MS/MS methods for metabolomics in patient materials.
• Performing LC‑MS/MS metabolomics analyses in clinical utility studies within innovation projects.
• Interacting with senior scientists on metabolomics and (glyco)proteomics.
• Contributing to a database of metabolite features (MS/MS fragmentation data, ion mobility data).
• Performing sample preparation, quality control, and data acquisition.
• Contributing to infrastructure development (LIMS, data linking).
• Collaborating with biobank coordinators and contributing to procedures related to informed consent.

You bring curiosity and energy to the table. You are proactive and enjoy collaborating within our team and with colleagues across the department. You are motivated, communicative, hard‑working, and adaptable, while keeping your eye on the team’s goals.

Your profile:

• A degree in analytical sciences with a focus on mass spectrometry.
• More than 3 years of experience in method development for high‑resolution mass‑spectrometry‑based metabolomics.
• Solid knowledge of chromatography and mass spectrometry, including fragmentation methods.
• A self‑motivated, project‑oriented work ethic with a collaborative attitude.
• Effective communication skills in English.
• Results‑oriented, flexible, and with a team‑first mindset.

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• A gross monthly salary between € 3.430 and €4.562 (scale 8) for full-time employment (36 hours per week). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and, depending on the position, an allowance of 47% to 72% for working irregular hours.
• 176 vacation hours per year based on a 36-hour working week.

At Radboudumc, you will work in a highly collaborative, interdisciplinary, and international environment. We are a leading European center for genomic medicine and rare disease research, with strong connections to clinicians, patients, and European initiatives such as ERDERA. What sets us apart is our unique position at the interface of fundamental mass spectrometry developments, genome sequencing and patient care. This ensures that your work will have direct clinical relevance and impact.

You will join a group that combines mass spectrometry excellence and functional genomics readouts with method development for clinical diagnostic applications. Our team consists with experts on proteomics, glycoproteomics and metabolomics and will now be expanded with a senior scientist and technician on mass spectrometry methods for novel metabolomics applications.

You will have access to unique sample collections, high-end mass spectrometry infrastructure, genome data and advanced computational infrastructure. The mass spectrometry infrastructure consists of several QqQ LC-MS/MS mass spectrometers for targeted metabolite diagnostics, two LC-QTOF systems for metabolomics and intact protein analysis, and two timsTOF systems for proteomics and glycoproteomics. The position is based at Radboudumc in Nijmegen, the Netherlands.

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where our research groups strive for innovative solutions that make impact on health and healthcare. We challenge the status quo to overcome current and future health challenges. Our goal is to shape the future of healthcare for generations to come. Our focus is on prevention, sustainability, and meaningful care, which we achieve through our in-depth understanding of disease mechanisms, clinical science, public health research, medical technology and data science. Our approach is centered on breakthroughs that can truly enhance personalized healthcare and public health.

At Radboudumc, a comprehensive range of research programs provide the compass for our research efforts. Each program has a clear goal, where collaboration within and outside our organization is highly valued. We integrate care, education and research in partnership with our patients to ensure that our research programs have significant impact on health and healthcare. We invite you to join us in our mission to create a healthy future for all.

Any questions? Or wondering what it is like to work at Radboudumc? Then email to Prof.dr. Dirk Lefeber, Full Professor. Use the Apply button to submit your application.