Multimodal MRI biomarkers in preclinical Alzheimer’s disease

You will investigate early vulnerability of the brain in preclinical alzheimer using large multimodal MRI datasets from a European cohort of cognitively unimpaired individuals at risk of the disease. You analyse structural, diffusion, perfusion, and functional MRI measures to identify network and microstructural alterations that precede symptoms. You integrate MRI-derived features with biological and clinical markers to improve disease-progression models and early prediction.

Would you like to know more about the different phases within the PhD trajectory? You can read more about this on this page.

Your work includes:

• development and application of image-processing pipelines;
• multivariate modelling using network analysis and machine-learning techniques;
• interpretation of multimodal patterns of brain organisation;
• collaboration with international partners in alzheimer prevention;
• contribution to methodological innovation in neuroimaging.

You work in a multidisciplinary environment that combines technical expertise with clinical relevance.

We are looking for an enthusiastic and motivated researcher with a strong interest in multimodal neuroimaging and clinical translation. You have:

• a master’s degree in technical medicine, neurosciences, neuropsychology, biomedical sciences or a related field;
• experience with neuroimaging processing and analysis;
• programming skills in, for example, R, Matlab or Python;
• affinity with alzheimer and other neurodegenerative disorders;
• good communication skills in written and spoken English.

• A flying start to your career in scientific research.
• Plenty of room for your drive to shape tomorrow's healthcare.
• Working on large-scale and in-house research, with motivated colleagues from all over the world.
• You will be employed by Amsterdam UMC Research BV.
• A contract for 12 months, with the intention to extend for a total of 4 years. The Guideline PhD contract applies to this vacancy.
• Salary scale OIO: € 3.108 to € 3.939 gross based on full-time employment (depending on education and experience) and a year-end bonus of 8.3%. Calculate your net salary here.
• Holiday hours: 190.4 per year for fulltime and a possibility to save additional hours.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
• For >7 km each way, 100% reimbursement for public transport travel costs and, for private transport, €0.18 per km up to a maximum of 40 km each way.
• Do you prefer walking or cycling? Take advantage of our good bike scheme. Moreover, you will receive a reimbursement of €0.18 per km.

Watch this video with more information about joining Amsterdam UMC Research BV.

You will work at the department of Radiology and Nuclear medicine. The department conducts high-quality multidisciplinary research on alzheimer and related dementias. You join an active imaging group led by prof. dr. Frederik Barkhof, where neuroradiologists, physicists, clinicians and data scientists collaborate on cutting-edge methods. The team offers an international atmosphere with strong links to leading European initiatives in alzheimer prevention.

You work with colleagues who value cooperation, curiosity and scientific integrity. The team culture is open, supportive and focused on shared progress in clinically relevant research.

Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided.

Watch the video to find out more.