The ambition of Vrije Universiteit Amsterdam is clear: to contribute to a better world through outstanding education and ground-breaking research. And to be a university where personal education and societal involvement play a leading role. Where people from different disciplines and backgrounds work together on innovations and on generating new knowledge. Our teaching and research embrace the whole spectrum of science – from the humanities, the social sciences and the pure sciences through to the life sciences and the medical sciences.
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About the projectThe AntiHelix consortium includes the following 9 European institutions as Beneficiaries: Consiglio Nazionale delle Ricerche, Naples, Italy; Elettra Sincrotrone SCpA, Trieste, Italy; University of Copenhagen, Denmark; Vrije Universiteit Amsterdam, Netherlands; University of Sheffield, United Kingdom; University of Duisburg-Essen, Germany; Lead Discovery Center GmbH, Dortmund, Germany; Edelris SAS, Lyon, France; Lumicks BV, Amsterdam, Netherlands. The AntiHelix program is coordinated by Dr Francesca M. Pisani (Istituto di Biochimica e Biologia Cellulare, Consiglio Nazionale Ricerche, Naples, Italy).
Project background and aimsHelicases are ubiquitous enzymes, found in viruses, Bacteria, Archaea and eukaryotic cells. They act as motor proteins to separate or remodel DNA or RNA duplexes, using ATP as an energy source. Their activity is essential in nucleic acid metabolism, playing a key role in a variety of cellular processes, including DNA replication, repair and recombination, as well as RNA translation and transport. Not surprisingly, given their essential tasks in living organisms, they are emerging as an important class of targets for antiviral, antibiotic and anti-cancer drugs. To date, several genetic and biochemical studies have revealed the molecular and physiological functions of DNA helicases. In addition, protein three-dimension structural studies coupled with single molecule biophysical approaches have provided insights into structure-function relationships and reaction mechanisms of some key DNA helicases.
The AntiHelix consortium includes experts in Biochemistry, Molecular Biology, Medicinal Chemistry, Structural Biology, Biophysics and Clinical Oncology and aims to:
- obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases
- discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers
- address the need for training next generation scientists with complementary approaches and diverse techniques by secondments in different laboratories of the consortium
- promote a culture of collaboration between academic and private sectors and provide young scientists with the necessary experience and skills to exploit the full potential of research findings
- provide researchers at early stage of their career with greater opportunities to access an increasingly competitive job market
Vrije Universiteit ESR projects
- ESR7 - Project Title: Correlated Tweezers Fluorescence Microscopy to visualize and measure the interplay of the BLM complex with the chromatin-remodelling factor PICH on DNA Home institution: VU University of Amsterdam, The Netherlands Supervisor: Dr. Gijs J. L. Wuite Keywords: Biophysics; Biochemistry; Molecular biology, Correlative optical-tweezers fluorescence microscopy
- ESR13 - Project Title: Biophysical study of DNA helicase action mechanism Home institution: VU University of Amsterdam, The Netherlands Supervisor: Dr. Gijs J. L. Wuite Keywords: Biophysics, Biochemistry; Correlative optical-tweezers fluorescence microscopy
Benefits
- 3 or 4 -year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations for Early Stage Researchers
- Enrolment in a local PhD school
- Access to state-of-the-art research and supervision by recognized experts
- Participation in network-wide training activities, schools and conferences
- Secondments periods at other network partners’ labs