Birds are the main hosts of influenza A viruses, with viruses from 17 different hemagglutinin (HA) subtypes known to circulate. Most avian influenza viruses are low pathogenic (LPAIV), but viruses of the H5 and H7 subtypes can spontaneously convert to highly pathogenic avian influenza viruses (HPAIV) upon transmission from wild waterfowl to domestic poultry. This has occurred at least 47 times over the past 50 years. HPAIVs cause systemic infection with mortality rates of up to 100% in poultry and are a major burden for avian health, but also a constant zoonotic threat, as illustrated by the numerous mammalian spillover events observed during the current H5 HPAIV outbreak.

Despite the clear importance of this topic, we are lacking fundamental information about the genesis of HPAIV. Your work will focus on understanding the mechanisms, subtype and species-restriction of HPAIV emergence at the molecular level. Your experimental work will include basic techniques in virology (BSL2 and BSL3 levels), primary cell and continuous line cell culture, state-of-the art molecular biology, reverse genetics, biochemical assays, and next-generation sequencing.

We are looking for a junior PostDoc that is enthusiastic and highly motivated. You have:

• A PhD from an accredited academic program in Virology and a study background on Biology, Biochemistry, Biomedical or Molecular Life Sciences.
• Demonstrable experience with cell culture and various molecular and/or and virological techniques.
• An excellent command of the English language, both oral and written.
• Demonstrable experience with biochemical assays, organoid culture and bioinformatics (preferred).

• You will receive a temporary position for 2 years.
• The gross monthly salary amounts a maximum of € 4.292,- (scale 10).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

Erasmus MC

The department of Viroscience employs more than 110 employees of different disciplines and runs an extensive experimental research program on the epidemiology, pathogenesis, prevention and treatment of infections by human and animal viruses. All necessary equipment to carry out the research proposed is available within the setting of the department. The department of Viroscience harbors well-equipped clinical and experimental virology labs, in which all the virology, molecular biology, pathology and immunology techniques necessary for the project are operational.

You will be part of the team of Dr. Mathilde Richard, whose recent focus has been on the understanding of HPAIV genesis, emergence and evolution, and in which the necessary expertise and experience to receive necessary training and support is available.