In cancer research, the modulation of the tumor micro-environment (TME) has gained a forefront position. Recent studies have demonstrated that diagnosis and therapy selection for cancer patients may benefit significantly from the discovery and validation of changes in TME, in particular those that are related to immune evasion. At Erasmus MC Cancer Institute, we start a TME Screening Center including state-of-the art equipment, such as a Vectra 3.0, to deliver highly multiplexed in situ staining together with computer-guided quantification. This set up enables comprehensive analysis of density and spatial distribution of stromal cells, including different immune cells. The TME Screening Center covers studies into multiple types of tumors and therapies, is part of an integrative workflow including genomic and imaging analyses, and is supported by the Stichting Daniel den Hoed. In this project, multiplex stainings and their analyses are optimized and tested according to specific research questions using tumor tissues of large patient cohorts with known treatment history and clinical follow-up. In addition to a postdoctoral fellow, the center will also include experienced technicians.

• You have obtained your PhD in the field of Computational Technologies and/or Biology (preferred: Cellular Immunology).
• You are familiar with image analysis and writing/applying algorithms (preferred: with Vectra systems); and you are able to coordinate and supervise research tasks.
• You are able to acquire research funds, and are highly motivated to perform research, take initiatives, communicate easily and cooperate in a team of researchers and PIs.

Being able to present a certificate of good conduct is a condition for the appointment.

We offer a temporary position for a period of 2 years. The gross monthly salary amounts to a maximum of € 4.216,- (scale 10), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

The Department of Medical Oncology has a long-standing tradition in clinical and translational cancer research. The research activities of our department are organized into 5 different divisions: Translational Cancer Genomics and Proteomics, Translational Pharmacology, Translational Onco-Immunology, Clinical Trials, and Palliative and Supportive Care. Research at the laboratory of Tumor Immunology (Division of Translational Onco-Immunology) is involved in the following activities towards new or ongoing patient studies: T cell treatments; understanding and intervention with cross-talk between tumor cells and micro-environment; and immune monitoring of T cell phenotype and function.