The cerebral cortex is our information processing center serving higher cognitive functions, including language, memory and thought. The highly complex and integrative structure of the cortex requires coordinated control of progenitor pool amplification, neuronal subtype specification, migration and integration in neuronal circuitries. Disturbance of any of these processes has been linked to a variety of neurodevelopmental disorders, including common disorders such as autism and intellectual disability.

The aim of the project is to understand how transcription and chromatin regulators contribute to development of the cortex and how mutations in these regulators that are associated with neurodevelopmental disorders affect cortical development. We are using a combination of in vitro neural progenitor cell cultures for biochemical assays (e.g. protein purification, mass spectrometry, ChIP-seq, chromatin conformation capture) and in vivo mouse models and human cerebral organoids to assess the developmental impact of manipulating selected transcriptional regulators. The experimental work also involves immunohistochemistry and (live) confocal imaging.

Your responsibilities will include co-designing and performing experiments, data analysis, documenting and reporting results in lab- and departmental meetings and at (inter-)national conferences.

We are looking for an exceptionally talented, highly motivated candidate that holds an MSc degree in Biomedical Science, Neuroscience or a related field and has a strong interest in molecular and/or cellular technologies. Affinity with bioinformatics is a plus. You are an effective communicator, combining independent thinking with a collaborative attitude.

Being able to present a certificate of good conduct is a condition for the appointment

You will receive a temporary position for 4 years. The gross monthly salary is € 2.279 ,- in the 1st year and increases to € 2.919,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Erasmus MC

A healthy population and excellence in healthcare through research and education. This is what Erasmus MC stands for. Conducting groundbreaking work, pushing boundaries and leading the way. In research, education, and healthcare. We are practical people with a high level of expertise, working hard to improve and renew the healthcare of today and the public health of tomorrow.

The Developmental Neurobiology Group is part of the Department of Cell Biology, which houses innovative technologies and top-level facilities to support its research programs. The main focus of the department is on transcription regulation and genome organization in (neuro-)developmental and blood cell forming systems in order to understand cell differentiation. The department is embedded in the dynamic, internationally competitive research community of over 40 biomedical research labs within the Erasmus MC. The main language of the research community is English. During the PhD training, our students follow specialized lab courses organized by the Erasmus MC Graduate School.