As postdoc in the Department of Internal Medicine (section on Thrombosis and Hemostasis), you will be part of a project carrying out fundamental pathophysiological research into hereditary bleeding disorders, in this case von Willebrand disease. Isolated endothelial cells, known as blood outgrowth endothelial cells (BOEC), taken from blood of von Willebrand disease patients and healthy controls will be studied in vitro. The BOEC will be characterized in terms of morphology through laser confocal immunofluorescence and electron microscopic analysis, in terms of expression of endothelial-specific proteins using biochemical techniques, in terms of response to stimulating agents, and in terms of angiogenic characteristics using matrigel and migration assays. One of the additional aims of the project is to standardize the conditions for isolation, culture and characterisation of BOEC.

You should have obtained a PhD in a relevant area and have a background in Biology, Biomedical Sciences or similar. Experience in working with cell cultures, cell biology, microscopy techniques and in vitro experimentation is required while knowledge of von Willebrand disease is preferred but not essential. You should be able to work independently and collaborate well with other members of your research group, and possess an entrepreneurial spirit for trying new methodologies.

Fixed-term contract: two year.

You will be employed on the basis of a 36-hour week. Appointment is for the two year duration of the project. Your salary will depend on your qualifications and experience, with a maximum of € 4,194 gross per month based on a full time position (scale 10 of the Collective Labor Agreement for University Hospitals).

 The LUMC offers very favourable working conditions. You are entitled to 8% holiday pay, a Christmas bonus, a pension plan with the ABP and a pay supplement for irregular hours (if applicable). In addition, you can collect a favourable collective healthcare insurance from the University Medical Centre (UMC).

 The LUMC also offers great facilities when it comes to training, children's daycare and career advice, and you can benefit from various leave arrangements and other bonuses. You can find out more on our website.

Internal Medicine (Thrombosis and Hemostasis)

The LUMC is a center for medical innovation that aims to improve patient care through leading international research. To provide our patients with a safe and friendly environment, we need doctors, medical care specialists, support staff and academic researchers.

Our key strength is medical life-sciences and clinical practice, with an impressive infrastructure comprising state-of-the-art technology platforms and (translational) research facilities. The LUMC is therefore uniquely positioned in the emerging Dutch healthcare infrastructure to play a leading role in the new healthcare paradigm of prediction, prevention and personalized medicine.

 Within the Department of Internal Medicine, most of the Thrombosis and Hemostasis research is housed within the Einthoven Laboratory for Experimental Vascular Medicine. There is close collaboration with various national and international research groups and research is both fundamental and clinical.