We are looking for a candidate for a 4 years PhD project that will be carried out at the CNCR, VU Amsterdam. Recent studies have shown that apart from neurons, glial cells play a major role in synaptic function. As yet, it is unclear to what extent glial cells are also involved in synaptic dysfunction in Alzheimer disease (AD). The overall aim of the project is to obtain insight into the role of glia cells (astrocytes and microglia) in synapse dysfunction at an early stage of AD.  The candidate will be involved in the identification of glial factors that are involved in morphological and functional defects of the synapse in AD. The studies will involve analysis of mouse models and human post mortem tissue, using transgenic, proteomic and imaging techniques. We are looking for a candidate with an interest in molecular and cellular neuroscience. Experience with any of the techniques mentioned is an advantage. 
  

• MSc degree (or equivalent) in biology or biomedical science;
• Research experience in molecular and cellular biology;
• Fluent in English (spoken and written).

The initial appointment will be for a period of 1 year. After satisfactory evaluation of the initial appointment, it will be extended for a total duration of 4 years (PhD).
 
You can find information about our excellent fringe benefits of employment at http://www.workingatvu.nl like:
• remuneration of 8,3% end-of-year bonus and 8% holiday allowance;
• solid pension scheme (ABP);
• a minimum of 29 holidays In case of full-time employment;
• a wide range of sports facilities, which staff may use at a modest charge. 
 
The salary will be in accordance with university regulations for academic personnel, and amounts € 2.222 ,- gross per month in the first year up to € 2.840,- in the fourth year (salary scale 85, PhD) based on a full-time employment.

Vrije Universiteit Amsterdam

Vrije Universiteit Amsterdam (VU) is a leading, innovative and growing university that is at the heart of society and actively contributes to new developments in teaching and research. Our university has ten faculties, and provides work for over 4,500 staff and scientific education for more than 23,000 students.

The Department of Molecular and Cellular Neurobiology (www.mcn.cncr.nl) at the Center for Neurogenomics and Cognitive Research in Amsterdam (see www.cncr.nl) is seeking applicants for a PhD in Neuron-Glia interactions. Research at the MCN department aims to identify mechanisms of synaptic function and plasticity across many levels of organization, from molecules up to behavior in animal models of human brain disease. The position is in the team of Mark Verheijen; Glial Regulated Neuronal Plasticity, which aims to discover new glial-based mechanisms of information processing in the brain in health and disease, with a focus on the role of astrocytes in the regulation of synaptic plasticity.