The Department of Pediatrics at the University Medical Center Groningen, the Netherlands, is looking for a highly motivated PhD student to assess the contributions of microbiome-derived signals in the etiology of age- and obesity-related cardio-metabolic diseases through (immune) senescence.
Background:
Cardiovascular disease (CVD) remains the number one cause of death worldwide. Atherosclerosis, the underlying pathology of CVD, is known as a lipid-driven inflammatory disorder. Although there are drugs that can successfully reduce the risk of CVD, there remains a substantial residual risk to resolve. This project is a part of “Inflammatory Reprogramming by Ageing and Microbiome – Targets for Treatment of Cardiovascular Disease” (IN-CONTROL II), a large, national project funded by CardioVascular Onderzoek Nederland (CVON).
The Department of Pediatrics at the University Medical Center Groningen aims at understanding the molecular principles of metabolic health and mechanism underlying the development of inborn and acquired diseases. We are interested in understanding the etiology of various complex diseases, with a specific focus on inflammation, dyslipidemia and cardiovascular disease. In the recent years, we have developed a powerful combination of techniques (e.g. CRISPR/Cas9 technology, proteomics) and in vivo models to study molecular mechanism that are involved in the above-mentioned pathologies. This knowledge will be applied to improve diagnostics and/or effective prevention and treatment.
The candidate will perform mechanistic studies in conventional and germ-free mice to quantify the causal role of the microbiome in immunological aging and evaluate the contribution of bile acid (metabolism) to cardio-metabolic risk development. You will perform mechanistic studies in mice to evaluate the development of cellular senescence in target tissues (heart, fat, liver) and immune functions in relation to atherosclerosis and cardiac dysfunction. In addition, you will evaluate relevant aspects of CVD (microbiome composition, metabolic profile, cardiac function) and immune functions in mice upon removal of senescent cells and/or novel pharmacological modulators. Cells and tissues samples will be analyzed at the cell biological (immunofluorescence), transcriptional, and biochemical (proteomics) level. Under dedicated supervision, you will be responsible to successfully complete your PhD training program, present at national/international scientific conferences, and report in scientific renowned journals.