Position 1: Development of treatments for cardiopulmonary complications after radiotherapy
We are looking for a highly motivated and ambitious postdoctoral scientist with a background in cardiology, oncology, radiation biology or similar to join our labs on a Dutch cancer society (KWF) funded highly multi-disciplinary project on the development and testing of pharmacological interventions for radiation-induced cardiac and pulmonary toxicity of radiotherapy treatment.
Cardiac and pulmonary toxicity are frequent side-effects of radiotherapy for thoracic tumors. Moreover, there is increasing evidence the benefit of radiotherapy is reduced by the risk of death from these toxicities. Interestingly, preclinical work suggests that mechanisms of these toxicities closely resemble those observed in patients suffering from cardiac failure from other causes. These patients are effectively treated in Cardiology practice. Therefore, the present project aims to test the effectiveness of these treatments to prevent radiotherapy-induced cardiopulmonary toxicity.
Position 2: pluripotent stem cell therapy for radiation-induced hyposalivation.
We are looking for a highly motivated and ambitious postdoctoral scientist with a background in stem cell biology, molecular biology, radiation biology or similar. The successful candidate will join our labs to work on a
Dutch Cancer Society (KWF) funded highly multi-disciplinary project, aimed at remodeling and rescuing radiation damaged salivary glands using iPS- derived stem cell-based therapy.
Salivary glands can be severely damage by radiotherapy for head and neck cancer, resulting in hyposalivation and consequential Xerostomia (dry mouth syndrome). This results in impairment of speech, taste and eating, an increased risk of oral infections and dental caries, all severely affecting the quality of life of the patients. The current project aims to find means to alleviate these effects.
The positions are at the Department of Radiation Oncology at the UMCG, while working within the section of Molecular Cell Biology at the Department of Biomedical Sciences of Cells and Systems.
Position 1 is headed by Dr. P. van Luijk, whose group’s main research interest is prediction, prevention and repair of radiation-induced normal tissue side-effects, in close collaboration with the department of Experimental Cardiology headed by Prof. Dr. R.A. de Boer, whose group focusses on translational cardiology and heart failure, and Prof. Dr. S. Brandenburg whose group operates a facility for high-precision proton irradiation used in the project.
Position 2 is headed by Prof. Dr. Rob Coppes, whose group’s main research interest is prediction, prevention and repair of radiation-induced normal tissue side-effect, Dr. Marco Demaria, whose group focusses on senescence and aging and Dr. S. Pringle whose group is developing iPS cell derived salivary gland cells.