Radboud University Medical Center (Radboudumc) Nijmegen sets out to attract an excellent hospital pharmacist, clinical pharmacologist and prominent expert in the field of pharmacokinetics and -dynamics in TB pharmaceuticals for a chair in Translational pharmacology of antimicrobial agents, in particular pharmaceuticals for tuberculosis. This position will be placed in the Pharmacy department of Radboudumc. We wish for the new professor, with excellent track record and research network, to help bring our medical center to a leading position in this field while strengthening innovative pharmacological research and multidisciplinary and international co-operations.

The Radboudumc aspires to have 'a significant impact on healthcare'. Within the field of infection diseases, Tuberculosis has been identified as the most important cause of death worldwide. Radboudumc has a strong foothold in poverty related infection diseases as TB and other mycobacterial infections. This chair is embedded within the research theme Infectious Diseases and Global Health and the Radboud Institute for Health Sciences (RIHS). Expertise in this field is being bundled in the Radboud Center for Infectious diseases (RCI) and the specialist group therein for mycobacterial infections (NTM).

Research
The chair aims to provide in a translational (from bench to bedside), application oriented pharmacological TB research line, in order to optimize TB treatment starting from the principle that the effect of TB medicine depends on both the achieved concentrations of these pharmaceuticals in plasma and their operative locations. Goal is to optimize the dosage of medicine(combination) based on the pharmacokinetics and pharmacodynamics of the medicine.

International networks and multidisciplinary partnerships are of the essence to TB research. Collaborations are in place with UMCG, ErasmusMC, United Kingdom, Germany and Sweden and with centers in Indonesia, Tanzania, South Africa and other African countries. New innovative methods and techniques need to be developed and new insights from successive pharmacological research phases need to be translated to populations and individual patients.

Patient care
The professorship will contribute to "personalized healthcare' in TB and other bacterial infection diseases by active participation in the existing Multidisciplinary Teams (MDO) with regard to TB and NTM infections. The chair will supervise the operations on blood level determination for medicine for mycobacterial infections (TDM) and initiate development of new determinations in the laboratory of the Pharmacy.

Education and training
The curriculum of the student education for Medicine differentiates from that of other university medical centers by extensive focus on tropical/poverty related infectious diseases. The new to be appointed professor is asked to take active part in the curriculum and in student electives in the field of this chair., in coordination with partners in the RCI.

The Pharmacy department directs the education for hospital pharmacist and the education for clinical pharmacologist. The chair is asked to teach in the specific field of pharmacology and research. Furthermore, the chair is expected to participate in training 'AIOS' (residents) in hospital pharmacy and clinical pharmacologists.

Qualities we look for in the new professor of Translational Pharmacology of antimicrobial agents, in particular pharmaceuticals for tuberculosis:

• You are both an experienced hospital pharmacist and a clinical pharmacologist.
• You are experienced in consulting on pharmacology for TB patients and in Therapeutic Drug Monitoring (TDM).
• You have excellent leadership skills: your work vision is based on giving and taking space and responsibility, openness, making clear agreements, holding each other accountable, connecting and sincere attention; you enable talent to flourish in the department and beyond.
• You are an effective communicator and connector, have an extensive international network and are adept at initiating sustainable networks, both internal (with the research institutes, research themes, and departments within Radboud university medical center) and external, worldwide.
• You have a clear vision of your profession; your strategic decisions are aligned with your vision.
• You act as a leading figure and ambassador to promote your field of research and the department.
• You have an excellent academic track record and you are internationally authoritative.
• You have experience with and are demonstrably successful in independently initiating, setting up, and conducting scientific research, and you are familiar with raising funds for research.
• You meet the Radboud university medical center criteria for "Principal Investigator", or can comply within 5 years.
• You are an inspiring lecturer.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

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