Peptidyl Arginine Deiminases (PADs) are calcium-dependent cysteine hydrolases responsible for the post-translational modification of peptidyl arginine to peptidyl citrulline and are involved in common cellular processes such as epigenetic histone modification and gene transcription. Despite recent evidence that dysregulation of PADs is associated with the onset of autoimmune disease, little is known about the exact role of PADs in these pathological processes.

In this two-year project you will study PAD and protein citrullination at a fundamental level and develop new methods to identify and target cellular interacting proteins. Your work will lead to a more fundamental understanding of protein citrullination and reveal novel therapeutic targets for treatment of several autoimmune diseases. Supervising and conducting experiments, both independently and in a team, is part of your work.

• A highly motivated and enthusiastic postdoctoral researcher who holds a PhD degree in Chemical Biology or a related discipline. 
• Experience in molecular biology and/or high resolution mass spectrometry is preferred but not required.
• Good communication skills in verbal and written English.

Fixed-term contract: 2 years.

• Employment: 32 - 40 hours per week (0.8 - 1.0 FTE).
• A maximum gross monthly salary of € 4,402 based on a 38-hour working week (salary scale 10).
• The exact salary depends on the candidate's qualifications and amount of relevant professional experience.
• In addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus.
• Duration of the contract: 2 years.
• The intended start date is 1 March 2021.
• You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment  and help your family settle in Nijmegen.
• Have a look at our excellent employment conditions. They include a good work-life balance (among other things because of the excellent leave arrangements), opportunities for development and a great pension scheme.

Radboud University

We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 22,000 students and 5,000 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!

Faculty of Science

The Faculty of Science is a complete, student-oriented science faculty where research and education are closely intertwined. The faculty aims to form an academic community with an international character, where staff members from different backgrounds can combine their talents with the common goal of being among the leading science faculties in Europe. 
The Institute of Molecules and Materials (IMM) is a research institute in chemistry and physics, which fosters interdisciplinary research. Its mission is to design and create functional molecules and materials in order to fundamentally understand their behaviour. IMM comprises 19 research groups active in areas ranging from condensed matter science to organic chemistry and chemical biology. We focus on fundamental research with an open eye for societal applications and help educate the next generation of leaders in science and innovation. IMM distinguishes itself from similar institutes by intensive collaborations and interactions between chemists and physicists and between experimentalists and theorists. IMM has a strong infrastructure including large user facilities such as the High Field Magnet Laboratory (HFML), the Free Electron Laser facility FELIX, and part of the uNMR-NL facilities. You will be part of the Bonger group which is embedded in the Synthetic Organic Chemistry department (SOC) of the Institute of Molecules and Materials (IMM). The Bonger group develops new chemistry and chemical biology approaches for targeted drug delivery and to study immune processes in health and disease.