Rabies virus (RABV), transmitted by a bite or scratch of an infected animal, causes RABV- encephalitis. After the initial infection the virus uses multiple ways to evade and suppress the host immune system, and hereby manages to travel to the brain unnoticed. Rabies mortality approaches 100% in human cases showing clinical signs but can be prevented by prophylactic vaccination or immediate post-exposure prophylaxis (PEP). PEP is effective but often too costly and unavailable to victims in most endemic areas. Alternative treatments are therefore urgently needed to reduce the annual burden of at least 60.000 reported deaths worldwide. Up to present the exact understanding of RABV pathogenesis, and the related immune response, has not been unravelled.

In the search of novel avenues for therapeutic intervention it is crucial to increase understanding of the immune response and pathogenesis of RABV infection. Your work will focus on identifying mechanism used by the virus to evade or suppress the host immune system. In later phases of the project, testing of novel post-exposure treatments will be included. You will work with both in vivo and in vitro models of RABV infection. Techniques will include flow cytometry, cytometric bead assays, virus neutralization assays, immunohistochemistry, confocal laser microscopy and primary cell cultures.

• You are an enthusiastic and highly motivated candidate, with a MSc degree in a relevant discipline (Biology, Biomedical or Molecular Sciences, Immunology, or (Veterinary) Medicine).
• Some experience with various molecular, immunological and/or and virological techniques is necessary. Experience with in vivo studies (art. 9 certified) and working in a BSL-3 safety level is an asset.
• You have excellent command of the English language, both oral and written.
• You are capable to interact with a diverse group of colleagues.

You will receive a temporary position for 4 years. The gross monthly salary is € 2.495,- in the 1st year and increases to € 3.196,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

Erasmus MC

The Department of Viroscience employs more than 110 employees of different disciplines and runs an extensive experimental research program on the epidemiology, pathogenesis, prevention and treatment of infections by human and animal viruses. All necessary equipment to carry out the research proposed in the projects is available within the setting of the department. The Department of Viroscience harbors well-equipped clinical and experimental virology labs, in which all the virology, molecular biology, pathology and immunology techniques necessary for these projects are operational.