We offer a 4-year PhD position at the Department of Molecular and Cellular Neurobiology (MCN) in the Center for Neurogenomics and Cognitive Research (
www.cncr.nl) Amsterdam. This is a ZonMW-funded FTD project that is part of a national consortium 'Mechanisms of Dementia'.
Do you have an (almost) completed MSc and ambition for research? Do you have a background in molecular neuroscience and affinity for computational analysis? Then this may be an interesting offer for you.
As a PhD candidate, you are involved in the consortium Mechanisms of Dementia. Our aim is to understand the underlying causes of dementia. Your research contributes to a team effort to better understand the cause of FTD, which is instrumental for designing future treatment strategies. You are part of the Graduate School Neurosciences Amsterdam-Rotterdam.
Frontotemporal dementia (FTD) is a devastating, rapidly progressing, neurodegenerative disease. In FTD, there is a wide spectrum of genetic and non-genetic causes and neuropathological and clinical phenotypes. This project aims at understanding the molecular events that take place during the early disease process. You study this using new combinations of multi-omics and computational approaches. The goal of this project is to reveal the potential mechanisms at the origin of the disease, which opens the possibility of targeted treatment.
In this project we use proteomics and transcriptomics technology to identify the changes in gene and protein expression in progressively affected tissue of the postmortem human FTD brain. You pay specific attention to molecular disease signatures in different brain areas as well as in gradients of affected tissue. You analyze both cell-specific and spatial information.