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A PhD Candidate to work on a genetic screen to identify genes that are required for axonal maintenance. After screening ~20% of the Drosophila genome, we have identified ~45 mutant lines that display axonal degeneration, showing that the screening approach works.
You will work on the characterisation of mutants already identified, and the generation of additional mutants, followed by whole genome sequencing and bio-informatic analysis to identify causative mutations, and putative disease-causing mutations in the human orthologous genes. You will further have the opportunity to contribute to other ongoing projects in our lab and be able to use a broad spectrum of methods and techniques including Drosophila genetics and behavioural analysis, fluorescence and confocal microscopy (and if applicable also super-resolution and electron microscopy), Illumina next-generation sequencing, immunohistochemistry, molecular biology and biochemistry. You will be expected to supervise Master's students. Beyond that, your exposure to teaching will be minimal.
Fixed-term contract: You will be appointed for an initial period of 18 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 2.5 years.
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