This 2.5-year post-doc position is funded by a Health Holland PPP Allowance Grant and PacingCure B.V. The project investigates the development of lentiviral gene therapy-based biological pacemakers that will be tested in human induced pluripotent stem cell (hiPSC)-derived cells and animal models. Our ultimate goal is to realize and expand the clinical applicability of gene therapy-based biological pacemakers to treat slow heart rhythm disorders (bradyarrhythmias). As a Post-doc you will work in the AMC and in the Laboratory of Experimental Cardiology, Leiden University Medical Center (LUMC) on optimizing gene therapy-based biological pacemaker constructs. Moreover, you will focus on testing novel therapies in small animal models of bradycardia, including optogenetics. You will join an enthusiast and dedicated team of researchers with different backgrounds, ranging from biology to medicine, engineering and physics. You will have access to fully equipped and operational laboratory spaces, while technicians will provide hands-on assistance whenever needed. See website for more information: https://www.medischebiologie.nl/boink-group/ & https://hartlongcentrum.nl/research/laboratory-of-experimental-cardiology/. You are expected to design experiments, conceptualize therapeutic improvements, and interact with the different team members/consortium partners to maximize scientific and therapeutic outcomes.

Candidates should have a Master’s degree in a life science subject, a genuine (and preferably proven) interest in cardiac electrophysiology/arrhythmias and gene therapy, an excellent higher education track record and strong scientific curiosity. Fluent spoken and written English skills are required. We seek a highly motivated scientist who enjoys an interdisciplinary environment. You are able to work independently but also as part of a team, and possess good communication skills.

Fixed-term contract: 2,5 years.

We offer you ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at AMR means working in an inspiring and professional environment where development is encouraged in every respect.

• The maximum gross monthly salary based on a 36-hour work week is € 4.481,- (scale 10 CAO UMC).
• The base salary does not include holiday pay (8%) and a year-end bonus (8.3%).
• The position is for a period of 2,5 years (initially 1 year, followed by at least 1,5 years if both parties agree). You will work in the Amsterdam UMC location AMC and in the Laboratory of Experimental Cardiology, LUMC, Leiden.
• In addition to excellent accessibility by public transport, AMC also has a sufficient number of parking spaces for employees.
• Pension is accrued at Be Frank.

For an overview of all our other terms of employment, see https://werkenbijamc.nl/arbeidsvoorwaarden-amr/.

Amsterdam Medical Center (AMC) 

Departments of Medical Biology

The Departments of Medical Biology of the Academic Medical Center Amsterdam and the Laboratory of Experimental Cardiology of the Leiden University Medical Center have joined forces to develop advanced biological therapies for cardiac arrhythmias. Exchange of researchers, ideas, equipment and reagents, combined with a common mindset and passion for innovative science, is at the very core of this collaborative effort. Equally important is a vibrant and challenging yet pleasant work environment, which is why all sort of social activities are organized to further strengthen the team spirit (see Files on lab website).