The PhD project entitled "A functional tissue-generating patch for diaphragmatic hernia closure (DIAPATCH)" is a collaborative research project of Radboud university medical center and University of Twente, financed by the Netherlands foundation for scientific research NWO. The general aim is to develop a skeletal muscle-generating patch to close the opening in the muscular diaphragm of children born with CDH (congenital diaphragmatic hernia).
The biodegradable patch will consist of biological and synthetic polymers, and will have tuneable strength, toughness and biodegradability. Upon implantation of the patch in diaphragm defect, skeletal muscle cell ingrowth will be facilitated by a radial pore structure and biochemical cues. At the Radboud university medical center, a PhD candidate will conduct the biological part of the project, whereas the polymer-chemical part of the project will be carried out by the PhD candidate at the University of Twente. Moreover, four companies, two clinical departments and one patient organization are involved in the project.Tasks and responsibilities
The PhD candidate will:
- design and perform scientific research in the area of biomaterials and regenerative medicine.
- generate and analyse the data in order to contribute to scientific publications and presents findings at scientific meetings.
- work in a team with other students and scientists to discuss, plans and performs research in a stimulating environment.
- complete the project with a scientific dissertation.