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Macrophages contain over 100 distinct lysosomes. Little is known about their precise composition, specifically with respect to their working horses, the hydrolases. The project will increase insight by a combination of chemical biology, biochemistry, cell biology and organic chemistry. Use will be made of activity-based probes that can specifically labeling and visualize lysosomal glycosidases and proteases. Applied will be rapid purification of lysosomes and their analysis through metabolomics and proteomics. The role of stress factors on lysosome composition will be investigated by determination of their composition and transcriptional regulation.
We offer a position for initially one year. After a positive evaluation of the progress of the thesis, personal capabilities and compatibility, the appointment will be extended by a further three years. Salary range from € 2,395.- to € 3,061.- gross per month (pay scale P in accordance with the Collective Labour Agreement for Dutch Universities).
Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. For international spouses we have set up a dual career programme. Candidates from outside the Netherlands may be eligible for a substantial tax break.
All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness.
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.
The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development is top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future.
The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organized in eight institutes. These institutes offer eight bachelor’s and twelve master’s programs. The faculty has grown strongly in recent years and now has more than 1,300 staff and almost 4,000 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together.
The chemistry and life science research in the Leiden Institute of Chemistry (LIC) is organized around two major research areas: ‘Chemical Biology’ and ‘Energy & Sustainability’. The institute’s research themes illustrate the central position of chemistry between biology, medicine and physics. The various research topics carried out within these themes are ideal for executing interdisciplinary research.
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