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PhD research project
Each year, over 1.5 million people worldwide develop primary or secondary (metastatic) liver cancer. Liver tumors are characterised by their limited treatment options and the relatively high 1-year mortality. Selective Internal Radiation Therapy (SIRT), also called radioembolization, is a treatment option for patients suffering from liver tumors that do not benefit from conventional therapy such as surgery or chemotherapy. During the treatment, radioactive microspheres are injected into the liver artery that supplies the tumor, where they lodge in and around the tumor and deliver a high local radiation dose. A crucial aspect to obtain an optimal treatment result is an effective distribution of the microspheres in the vascular network of the liver.
Computational modeling has evolved as a useful tool that can help in understanding optimal distribution of microspheres, among other aspects. In this project, funded by the Netherlands Organisation for Scientific Research (NWO) we will develop a particle transport model within the lattice Boltzmann framework Musubi to study the optimal microsphere distribution using simulations on high performance supercomputers. The PhD candidate will actively collaborate with two other PhD students in this project involved in experimental and clinical aspects. Collaboration and exchange with hospitals like the Radboud University Medical Center, Nijmegen, the Multi-Modality Medical Imaging group and Physics of Fluids group at the University of Twente will form regular part of the activities of the PhD candidate. The project description can be found under: https://www.radboudumc.nl/en/news/2020/research-on-improved-irradiation-of-liver-tumors-from-within
You will be positioned in the Engineering Fluid Dynamics group of the University of Twente, and you will be a part of a dynamic, multidisciplinary team. The main advisor of your project will be Assistant Professor Dr. Kartik Jain (https://jainka.github.io). You will collaborate with the group of Associate Professor Dr. Frank Nijsen at the department of Medical Imaging, RadboudUMC in Nijmegen and Assistant Professor Dr. Erik Groot Jebbink at the University of Twente.
You first responsibility is to carry out the research, but you are also encouraged to acquire teaching experience. We support you to broaden your knowledge by joining international exchange programs, by participating in national and international conferences and workshops and by visiting industrial companies, research institutes, and universities worldwide.
We offer you a very challenging position in an inspiring multidisciplinary environment. The university offers a dynamic ecosystem with enthusiastic colleagues in which internationalization is an important part of the strategic agenda.
University of Twente (UT)
Drienerlolaan 5, 7522 NB, Enschede
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