PhD position in Computational Systems Biology
PhD position in Computational Systems Biology
You cannot apply for this job anymore (deadline was 15 Aug 2021).
Browse the current job offers or choose an item in the top navigation above.
Job description
We offer a PhD position in Systems Biology at the University of Twente (UT). The successful applicant will join the Applied Analysis (AA) group at the Department of Applied Mathematics at the Faculty of Electrical Engineering, Mathematics and Computer Science. A strong collaboration with the Developmental BioEngineering (DBE) group is part of the position.
About the project:
Tissue engineering strategies have so far failed to succesfully make articular cartilage. The NWO project SCI-MAP explores the variability of cell differentiation using a systems biology approach. We work with biologists and tissue engineers to advance the use of induced pluripotent stem cells (iPSCs) in the clinical setting of joint diseases by determining and understanding key modifiable factors that direct and maintain stem cell differentiation into chondrogenic lineages.
Computational models have the potential to transform experimental biology by describing and understanding observations and ultimately to predict cell behavior. You will work at the interface of applied mathematics and biology developing new models incorporating data from the consortium. Through simulations and numerical bifurcation analysis you will assist with the design of new biological experiments. The PhD project will be carried out under the supervision of Dr. Janine Post (DBE) and Dr. Hil Meijer (AA).
About the project:
Tissue engineering strategies have so far failed to succesfully make articular cartilage. The NWO project SCI-MAP explores the variability of cell differentiation using a systems biology approach. We work with biologists and tissue engineers to advance the use of induced pluripotent stem cells (iPSCs) in the clinical setting of joint diseases by determining and understanding key modifiable factors that direct and maintain stem cell differentiation into chondrogenic lineages.
Computational models have the potential to transform experimental biology by describing and understanding observations and ultimately to predict cell behavior. You will work at the interface of applied mathematics and biology developing new models incorporating data from the consortium. Through simulations and numerical bifurcation analysis you will assist with the design of new biological experiments. The PhD project will be carried out under the supervision of Dr. Janine Post (DBE) and Dr. Hil Meijer (AA).
Specifications
- max. 40 hours per week
- €2395—€3061 per month
- Enschede View on Google Maps
:fill(white)/logos/ut-en-wide_G4Gv5hk.png)
University of Twente (UT)
Requirements
We look for a highly motivated, enthusiastic researcher who is driven by curiosity and:
- Has, or will shortly acquire, a master's degree in Mathematics, Biomedical Engineering, Systems Biology or a related field;
- Has experience with mathematical modeling and/or numerical bifurcation analysis;
- Has a strong interest in systems biology, or is willing to acquire such knowledge;
- Experience in analysis of big data (transcriptomics, proteomics) and chondrogenesis/cartilage will be considered a benefit;
- Is proficient in programming to solve complex problems with data and numerics;
- Is a team player with good communication skills;
- Is proficient in English, both spoken and written.
Conditions of employment
The terms of employment are in accordance with the Dutch Collective Labour Agreement for Universities (CAO) and include:
- A fulltime PhD position for four years, with a qualifier in the first year;
- Full status as an employee at the UT, including pension and health care benefits;
- The salary will range from € 2.395 (1st year) to € 3.061,- (4th year) per month, plus a holiday allowance of 8% and a year-end bonus of 8.3%;
- A solid pension scheme;
- Excellent facilities for professional and personal development.
Department
Department of Applied Mathematics
The faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) uses mathematics, electronics and computer technology to contribute to the development of Information and Communication Technology (ICT). With ICT present in almost every device and product we use nowadays, we embrace our role as contributors to a broad range of societal activities and as pioneers of tomorrow's digital society. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.
Specifically, the Applied Analysis group focusses on the combination of models, machine learning and uncertainty quantification to advance methods for and understanding of clinical data.
Department of Developmental BioEngineering
The department of Developmental BioEngineering is a research group with a highly international character. The main goal of this group is to investigate novel and challenging technologies and science in the field of Regenerative Medicine, which can be used for tissue repair. Research focuses on i) Fundamental aspects of joint and cartilage homeostasis, ii) Cell therapy for treatment of joint disorders, and iii) Injectable, in situ gelating extracellular matrices for soft tissue repair.
The faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) uses mathematics, electronics and computer technology to contribute to the development of Information and Communication Technology (ICT). With ICT present in almost every device and product we use nowadays, we embrace our role as contributors to a broad range of societal activities and as pioneers of tomorrow's digital society. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.
Specifically, the Applied Analysis group focusses on the combination of models, machine learning and uncertainty quantification to advance methods for and understanding of clinical data.
Department of Developmental BioEngineering
The department of Developmental BioEngineering is a research group with a highly international character. The main goal of this group is to investigate novel and challenging technologies and science in the field of Regenerative Medicine, which can be used for tissue repair. Research focuses on i) Fundamental aspects of joint and cartilage homeostasis, ii) Cell therapy for treatment of joint disorders, and iii) Injectable, in situ gelating extracellular matrices for soft tissue repair.
