You cannot apply for this job anymore (deadline was 29 Oct 2021).
Browse the current job offers or choose an item in the top navigation above.
Would you like to contribute to expanding our knowledge of the molecular interactions within a cancer cell? As a PhD Candidate, you will broaden our understanding of disease mechanisms in cancer and our ability to design effective therapies. This way, you help us improve the prevention, detection and treatment of cancer.
Cancer is a group of complex diseases frequently exhibiting deregulated gene expression and metabolism. This complexity resides in both the large number of molecules that are involved (transcripts, proteins, metabolites, and so on), and in the intricate interactions that these molecules can have with each other. A significant challenge in the area of cancer research today is that much of these interactions are yet unknown.
As a PhD candidate, you will contribute to the expansion of this knowledge, broadening our understanding of disease mechanisms in cancer and our ability to design effective therapies. The research in our lab includes both experimental (‘wet-lab’) and theoretical (‘dry-lab’) components. You will have the opportunity to: design and conduct a range of experiments in 2D and 3D tissue culture using breast cancer cell lines; analyse transcriptomics, proteomics, metabolomics, and fluxomics data; build and finetune quantitative models of gene expression, metabolism, and their interactions; and computationally simulate cancer cell behavior to develop novel theoretical viewpoints. You will gain a strong foundation in the molecular and systems biology of cancer cells, state-of-the-art omics technologies, and computational approaches to integrate multi-omics ‘big data’.
You will be working in an interactive and multidisciplinary environment in the Molecular Developmental Biology group at RIMLS, under the supervision of Dr Rosemary Yu. As part of your PhD training, you will assist in one or two courses a year and supervise BSc and MSc students within the context of your project.
Fixed-term contract: 4 or 5 years.
The Radboud Institute for Molecular Life Sciences (RIMLS) is a leading interfaculty research institute of the faculties of Science (FNWI) and Medicine (Radboud university medical center). The overarching aim of RIMLS is to decipher molecular mechanisms of disease. Research areas of RIMLS-FNWI include epigenetics, stem-cell and developmental biology, and computational biology. The central research theme is regulation of gene expression during development and in health and disease. Important tools used within the institute include next-generation sequencing, mass spectrometry, single-cell (multi-omics) analysis and computational analysis and method development. To perform state-of-the-art research, RIMLS-FNWI operates its own wet-lab and computational facilities. This fundamental and applied research in medical biology and molecular life sciences has clear links to biochemical research performed at the Institute for Molecules and Materials and other institutes of the Faculty of Science as well as to more clinically oriented research programmes at departments within the Radboud university medical center. RIMLS-FNWI actively contributes to teaching activities in the Biology study programme at Radboud University. RIMLS-FNWI currently has about 50 researchers (including 30 PhD candidates and postdoctoral researchers) and provides a vibrant and international working environment. The institute actively participates in various European and worldwide consortia and collaborations.
Radboud University
We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 24,000 students and 5,600 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!
We like to make it easy for you, sign in for these and other useful features: