Postdoc position: deep learning models for the implementation of parotid gland stem cell sparing radiotherapy to prevent permanent xerostomia.

The most-reported side-effect in patients treated with radiotherapy for head and neck cancer is dry-mouth syndrome (xerostomia), which might be permanent and has major impact on quality of life. However, preservation of parotid gland stem cells, located near the main parotid gland ducts might enable regeneration of glandular tissue and function. The relation between dose to the parotid gland and its stem cells, and its long-term function remains poorly understood preventing clinicians from using effective stem cell sparing treatment techniques. Therefore the aim of this project is to develop and validate prediction models that describe the role of the parotid gland stem cells in the development of therapy-induced xerostomia, and can be used directly in clinical practice to improve patient care.

You will develop these models together with a PhD-student, dedicated to this research project. Your tasks as a postdoctoral researcher will especially include the development of advanced models based on baseline patient characteristics with the addition of radiomics derived from multimodality imaging (CT, CBCT, MRI, PET) which are assessed before, during and after the course of radiation. You will be using techniques such as multi-level model analysis machine learning techniques (e.g. deep learning).

- PhD degree in medical physics, technical medicine, biomedical engineering or related discipline.
- Affinity with research and interest in clinical translation of research.
- Preferably experience with prediction modeling.
- Programming experience will be an advantage.
- Motivated, result-driven team player.
- Good social skills and flexible attitude.
- Fluency in English.

- We offer a temporary contract for 2 years, for 28,8 - 36 hours a week.
- After these 2 years, several possible professional development opportunities exist at the department.
- Preferred starting date: as soon as possible.

Your salary will be a maximum of € 4.800 gross per month (scale 10 from 1-8-22), depending on your qualifications and relevant experience, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Radiotherapie

With 400 employees and 4500 patients treated annually, the department of Radiation Oncology at the University Medical Center Groningen (UMCG) is one of the largest departments in the Netherlands using state-of-the-art treatment equipment. In addition, the department hosts the Graylines research institute in which a number of research groups world-leading in proton radiation therapy, stem cell and radiation biology, and medical applications of artificial intelligence, join their expertise to perform basic, translational and clinical research aimed at improving patient care.