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Become part of the new research consortium IMAGINE! (Innovative Microscopy And Guidance of cells In their Native Environment). Our programme aims to transform cell biology by developing and applying advanced microscopy and real-time molecular manipulation techniques to study cells in their natural complexity and diversity. The consortium will form a unique and highly interdisciplinary team that combines cell, organoid, and tissue biology, as well as chemical and optical cell manipulation to study cell behaviour in development, cancer, and targeted drug delivery.
In this PhD position at Utrecht University in the Akhmanova Lab you will develop methods to measure and mechanistically investigate cell type-specific effects of microtubule-targeting agents in intestinal, airway and mammary gland organoids. You will work together with the groups within the IMAGINE! project who also work on these systems and contribute to similar analyses in vivo (The Van Rheenen Group of The Netherlands Cancer Institute and the Friedl Group at Radboud UMC). In collaboration with the Prins Group (at Eindhoven University of Technology), you will work on the development of analytical methods to measure concentrations of microtubule-targeting agents in tissues. The overall goal is to “see drugs in action” within cells in tissue environment.
We are looking for a highly motivated and creative candidate to join us in this unique project. We would like you to bring:
If you feel that this role is the perfect match, but you do not yet meet all the qualifications, we also welcome you to apply.
In addition to the employment conditions laid down in the CAO for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment via the Employment Conditions Selection Model. This is how we like to encourage you to continue to grow.
For more information, please visit working at the Faculty of Science.
Utrecht University is a friendly and ambitious university at the heart of an ancient city. We love to welcome new scientists to our city – a thriving cultural hub that is consistently rated as one of the world’s happiest cities. We are renowned for our innovative interdisciplinary research and our emphasis on inspirational research and excellent education. We are equally well-known for our informal atmosphere and the can-do mentality of our people. This lively and inspiring academic environment attracts professors, researchers and PhD candidates from all over the globe, making both the University and the Faculty of Science a vibrant international and wonderfully diverse community.
At the Faculty of Science, there are 6 departments to make a fundamental connection with: Biology, Chemistry, Information and Computing Sciences, Mathematics, Pharmaceutical Sciences, and Physics. Each of these is made up of distinct institutes that work together to focus on answering some of humanity’s most pressing problems. More fundamental still are the individual research groups – the building blocks of our ambitious scientific projects. Find out more about the Faculty of Science.
You will be embedded in the Department of Biology of Utrecht University within the division of Cell Biology, Neurobiology and Biophysics. This division has the mission to acquire novel insights into the structure and function of cells and to decipher the cellular basis for human diseases such as cancer and neurological disorders. To achieve this goal, we combine the latest methods in molecular biology, biochemistry, genetics and microscopy. We are interested in the mechanisms underlying cytoskeletal dynamics, membrane transport and signalling pathways that underlie cell proliferation and differentiation, neuronal development and synaptic plasticity. We investigate cellular processes at a broad range of levels, from single molecules and protein networks to cells, tissues, and whole organisms. The main research topics within the division are cellular organization and dynamics, molecular neuroscience, biophysics, synaptic physiology, molecular oncology and molecular targeted therapies. The division also encompasses the Utrecht Nanobody Facility, the Cellular Engineering Facility and the Biology Imaging Center (BIC), an expert center for advanced light microscopy that houses a large number of advanced microscopy setups.
This position is one of many PhD and postdoc positions available as part of the gravitational programme IMAGINE! (Innovative Microscopy And Guidance of cells In their Native Environment). IMAGINE! is an interdisciplinary programme combining cell, organoid, and tissue biology, as well as chemical and optical cell manipulation and analysis to study cell behaviour in development and cancer, and targeted drug delivery. Participating institutes are based throughout the Netherlands in Utrecht, Amsterdam, Delft, Rotterdam, Nijmegen, and Eindhoven. For more information on the individual positions, please visit the IMAGINE! programme website.
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