We look for a dedicated data scientist for clinical and immunological research embedded in our international multi-disciplinary team which aims to improve understanding of the pathophysiology of tuberculous meningitis and thereby to improve its outcome. Will you join our team?
Tuberculous meningitis is the most lethal form of tuberculosis and the leading cause of meningitis in many global settings, disproportionally affecting infants and young children. Around 50% of adult patients die or remain disabled, and although children with tuberculous meningitis probably have lower mortality, they can suffer serious long term physical and neurocognitive sequelae. The development of novel therapeutic approaches is hampered by lack of knowledge concerning the biological pathways involved, and how existing (e.g. corticosteroids) and alternative adjunctive therapies (e.g. aspirin) improve clinical outcomes. We aim to increase our understanding of the pathophysiology and identify novel targets for host-directed therapies against tuberculous meningitis, funded by NIH (R01-AI145781-01).
Your job will be primarily to analyze and integrate multiple layers of data from well-phenotyped patient cohorts from Vietnam and Indonesia. You will be responsible for the processing of high-quality clinical and biological data, including metabolomics, proteomics and genomics.
Your job will include, but will not be limited to, identifying proteomic or metabolomic biomarkers that predict outcome of disease, linking these biomarkers to genetic variants. Potentially, we can perform a genome-to-genome analysis to unravel the host-pathogen interaction. The coordination and processing of new measurements will also be your responsibility.
We offer you:
- Supervision by multiple researchers, each with specific skills.
- Being part of a diverse and dedicated tuberculosis team.
- The possibility to supervise BSc and MSc students.
- Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. Van Laarhoven et al. Lancet Infectious Diseases 2018.
- Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data. Van Crevel. Tuberculosis 2021.