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Do you have a PhD in neuroscience and experience in molecular biology and cell structure? Then investigate how synapses form, function and can be maintained as a postdoc. Your research will focus on the molecular events that underlie these processes, and how impairments in these processes can lead to disease. You will work in a group within a world-class neuroscience institute with a lively and interactive culture.
Synapses in the brain live for months or even years. Their protein components, however, become dysfunctional after much shorter periods and therefore have to be removed continuously. Pathways for removing these damaged proteins include the ubiquitin-proteasome system, autophagy and the endo-lysosomal system. We are recruiting a postdoctoral researcher to investigate degradative mechanisms at presynapses, the role of the endo-lysosomal pathway in particular. We are also recruiting a postdoctoral researcher to map early dysfunction of neurons in Parkinson's disease. The postdoctoral researcher will investigate how alpha-synuclein aggregation in axons and synapses can disturb neurotransmission.
Our main model systems are primary rodent neuron cultures and human iPSC-derived neurons. As a postdoctoral researcher you will work independently on one or two projects. You will collaborate with and supervise PhD and Master's students. You will get some exposure to teaching, but only to a minor extent. In the long run, the development of an independent research project that can be transferred to a future position is possible and encouraged.
Fixed-term contract: It concerns a temporary employment for 2-3 years.
Houtlaan 4, 6525 XZ, Nijmegen
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