Our group aims to attain broader relevance of CAR T cell therapy through improvement of tumor targeting and tumor elimination, overcoming resistance, minimization of off-tumor toxicity and expansion of the availability across histocompatibility bariers. Specifically, we use synthetic immunology to develop novel engineering strategies, we apply multi-targeting of CAR T cells and investigate CAR T and drug combinations to improve the efficacy and specificity of CAR T cell therapy. Our scientific hypothesis are tested in
in vitro and
in vivo xenograft models. Our ultimate goal is to develop CAR T cell therapies that can be translated in clinical trials and improve the therapeutic outcomes of patients with hematologic but also solid tumors.
About your role
- You will work in a dedicated team of postdocs, PhD students and technicians and you will be supervised by an expert in the field of CAR T cell therapy;
- You will be mainly working in a BSL-II tissue culture laboratory and your main activities will be: production of viral vectors, generation of CAR T cells, evaluation of CAR T cell function in in vitro assays and in vivo cancer models;
- You will be performing molecular cloning and generating new CAR constructs;
- You will be performing multi-color flow cytometry.