PhD student for the Inflammation and Cancer group of dr. Karin de Visser
PhD student for the Inflammation and Cancer group of dr. Karin de Visser
Job description
Research group
The Inflammation and Cancer group of dr. Karin de Visser studies the impact of the immune system on breast cancer metastasis and response to anti-cancer therapies by utilizing sophisticated mouse tumor models and state-of-the art ex vivo and in vitro immunological and molecular assays.
Project
Primary breast tumours induce neutrophil expansion which we, and others, have shown to promote metastatic spread. In this project we aim to provide novel mechanistic insights into how breast tumors manipulate the phenotype and function of neutrophils in tumour-bearing hosts, leading to the generation of pro-metastatic neutrophils. To address this aim, molecular, mechanistic and intervention studies will be performed in preclinical mouse models of primary and metastatic breast cancer. In parallel, we will perform validation studies using patient samples.
Your task will be to perform experiments that provide insight into how tissue specification of neutrophils in tumour-bearing hosts impacts the development of a metastasis permissive environment, use intervention studies to understand if we can reverse pro-metastatic neutrophil functionality along with validation studies using patient blood samples. Your analysis will provide critical understanding of how neutrophils promote metastatic spread and how this functionality can be reversed which may ultimately contribute to the design of novel therapeutic strategies to reduce metastatic spread.
Specifications
- max. 36 hours per week
- Amsterdam View on Google Maps
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The Netherlands Cancer Institute
Requirements
We seek an ambitious, enthusiastic and highly motivated PhD student with an affinity for immunology and strong problem-solving ability. Previous experience with mouse models is required and a Dutch Article 9 or Felesa certification is desirable. In addition, experience with flow cytometry and other immunological techniques is a plus. Proficiency in English and strong communicative skills are important requirements, as is a team player mentality.
Conditions of employment
The gross salary for a fulltime appointment will range depending on previous experience. In addition, you will receive a fixed end-of-year bonus in December (8,33%) and in May you will receive 8,33% holiday pay.
For all secondary conditions visit: https://www.nki.nl/careers-study/how-to-apply/.
Additional information
Questions?
For further details on our research, please visit our website. For more information, please contact dr. Hannah Garner (h.garner@nki.nl).
Interested?
Applications can be submitted via the application button, and should include your CV (including contact information of your references), a motivation letter of maximally 1 page, and a copy of your Bachelor and Master grades.
Select reading
- Blomberg, O. S. et al. IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer. Cancer Cell (2023)
- Garner, H. & Visser, K. E. de. Immune crosstalk in cancer progression and metastatic spread: a complex conversation. Nature Reviews Immunology (2020)
- Wellenstein, M. D. et al. Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis. Nature (2019)
- Coffelt, S. B. et al. IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature (2015)
The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labour market, sexual orientation or gender identity.
Acquisition in regard to this vacancy is not appreciated.
Specifications
- PhD; Research, development, innovation
- Health
- max. 36 hours per week
- University graduate
- PA NKI 20230414
Employer
Location
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Application procedure
Applications can be submitted via the application button, and should include your CV (including contact information of your references), a motivation letter of maximally 1 page, and a copy of your Bachelor and Master grades.
The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labour market, sexual orientation or gender identity.
Acquisition in regard to this vacancy is not appreciated.
Application procedure
Application procedure
Applications can be submitted via the application button, and should include your CV (including contact information of your references), a motivation letter of maximally 1 page, and a copy of your Bachelor and Master grades.
The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labour market, sexual orientation or gender identity.
Acquisition in regard to this vacancy is not appreciated.
Make sure to apply no later than 12 Jun 2023 23:59 (Europe/Amsterdam).