PhD Single molecule biosensor for continuous monitoring of water pollutants

PhD Single molecule biosensor for continuous monitoring of water pollutants

Published Deadline Location
19 Apr 19 Jul Eindhoven

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Job description

  • We are developing a sensing technology with single-molecule resolution called Biosensing by Particle Motion (BPM). The technology is based on particles attached to a sensing surface that change their mobility due to the binding and release of analyte molecules.
  • Recent publications of our research are: 'Continuous biomarker monitoring by measuring free particle motion', Nature Communications (2022); 'Dynamic response limits of affinity based sensing', ACS Sensors (2022); 'Reversible immunosensor for cortisol in blood plasma sampled with microdialysis', ACS Sensors (2022).
  • Scientific questions relate to biomolecular architectures, signal processing and calibration methods, microfluidics, measurements in complex matrices.
  • Applications include real-time measurements for patient care, life science research, industrial process control and environmental monitoring.
  • The project gives opportunities to collaborate with academic and industrial partners, including spin-off company Helia Biomonitoring (
  • You will become a member of the Molecular Biosensing group (MBx, Laboratories are shared with the Institute for Complex Molecular Systems (
  • In this project we will expand the BPM technology for the detection of the pharmaceuticals diclofenac and 17β-Estradiol. Both compounds are found throughout Europe at critical concentrations that will threaten the environment in the coming years if they increase further.  


Eindhoven University of Technology (TU/e)


  • A Master's degree (or an equivalent university degree) in engineering or in analytical sciences, e.g., chemical engineering, biophysical sciences, biomedical engineering, analytical chemistry.
  • A research-oriented attitude.
  • Ability to work in an interdisciplinary team.
  • Motivated to develop your teaching skills and coach students.
  • Fluent in spoken and written English (C1 level).

Conditions of employment

A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station. In addition, we offer you:
  • Full-time employment for four years, with an intermediate evaluation (go/no-go) after nine months. You will spend 10% of your employment on teaching tasks.
  • Salary and benefits (such as a pension scheme, paid pregnancy and maternity leave, partially paid parental leave) in accordance with the Collective Labour Agreement for Dutch Universities, scale 27 (min. €2,541 max. €3,247).
  • A year-end bonus of 8.3% and annual vacation pay of 8%.
  • High-quality training programs and other support to grow into a self-aware, autonomous scientific researcher. At TU/e we challenge you to take charge of your own learning process.
  • An excellent technical infrastructure, on-campus children's day care and sports facilities.
  • An allowance for commuting, working from home and internet costs.
  • A Staff Immigration Team and a tax compensation scheme (the 30% facility) for international candidates.


  • PhD
  • Engineering
  • max. 38 hours per week
  • University graduate
  • V34.6579


Eindhoven University of Technology (TU/e)

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De Rondom 70, 5612 AP, Eindhoven

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