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Are you a scientist with a PhD degree or close to obtaining a PhD degree in Neurobiology or a related field, who is interested in a scientific career? Are you passionate about science and a critical and creative thinker? Are you interested in exploring the molecular mechanisms underlying motor neurodegenerative disease and performing cutting-edge biomedical research? Then you have a part to play as a postdoctoral researcher!
We are looking for a postdoctoral researcher who will work independently on Drosophila genetics projects. Your main project will involve the characterisation of mutant lines identified in a forward genetic screen for genes required for axonal maintenance (unpublished). These mutants display adult-onset progressive degeneration of peripheral motor and/or sensory neurons. Phenotypic and molecular characterisation of these mutants involves Drosophila genetic approaches, behavioural analysis, immunohistochemistry, fluorescent in situ hybridisation (FISH), in vivo non-canonical amino acid tagging (NCAT), confocal and super-resolution imaging, molecular biology, biochemistry, and next-generation sequencing. In addition, you will have the opportunity to contribute to other ongoing projects in the lab, such as studying the molecular pathogenesis of CMT peripheral neuropathy associated with mutations in tRNA synthetases, following up on our recently published work (Zuko, Mallik et al, Science, 2021). You will have the opportunity to collaborate with and supervise Master's students, and - in the longer run - also PhD candidates. You will get some exposure to teaching in Master's courses. Finally, the development of an independent research project that can be transferred to a future position is possible and highly encouraged.
Fixed-term contract: It concerns a temporary employment for 2 years.
The Storkebaum lab combines Drosophila and mouse genetics to unravel molecular mechanisms underlying motor neurodegenerative and neuromuscular disorders. Our current focus is on Charcot-Marie-Tooth (CMT) peripheral neuropathy associated with mutations in tRNA synthetases and on amyotrophic lateral sclerosis (ALS) associated with mutations in FUS. More broadly, we are interested in the molecular mechanisms underlying axonal degeneration, with a focus on the role of mRNA translation defects. We use a broad spectrum of methods and techniques including a recently developed method for cell-type-specific in vivo labelling of newly synthesised proteins (NCAT), several high-end imaging techniques (confocal and super-resolution microscopy), single-molecule FISH, (single-cell/single-nucleus) transcriptomics, whole genome sequencing, mouse and Drosophila behavioural analysis, electromyography, histology, immunohistochemistry, molecular biology and biochemistry.
Our dynamic and international team currently consists of three postdoctoral researchers, four PhD candidates and a technical assistant. Furthermore we have strong international collaborations with scientists working on RNA biology and genetics. We attracted substantial external funding, including an ERC consolidator grant, two JPND grants, and grants from the Radala Foundation for ALS Research, the Muscular Dystrophy Association (MDA), AFM, ARSLA, the Dutch ALS Association, Prinses Beatrix Spierfonds and the Dutch Research Council NWO. We have several recent papers published in high-impact journals, including Science, Nature, Neuroscience, Journal of Cell Biology, Nature Communications, Acta Neuropathologica, EMBO Journal and PLoS Genetics.
Houtlaan 4, 6525 XZ, Nijmegen
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