Associate Professor 'Innovative clinical trial design'

Associate Professor 'Innovative clinical trial design'

Published Deadline Location
4 May 15 Jun Nijmegen

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Job description

In the context of the Sectorplan Medical Sciences, Radboudumc center is offering an exciting and varied associate professor position for a senior statistician with interest in methodology of clinical research and drug development. Will you join our ambitious team?

Radboudumc aims to accelerate the development of rare disease therapies by filling the gap between preclinical and clinical science. The Sectorplan Medical Sciences provides funding for 13 structural positions to foster research and education in this field.

The field of clinical research in rare diseases urgently needs experience in innovative study designs and methodology. Due to the small populations and wide variety in diseases addressed, this innovation is essential to clinically explore effects of new treatments and to adequately confirm their efficacy to support licensing and reimbursement. This for example is the case for drug repurposing but also for innovative medications as gene- and cell-based therapies (ATMPs) such that new treatments really reach our patients.

We are searching for a statistician who has experience in clinical trials and their designs, and is strongly motivated to further develop this interesting field. You will have an active engaging and facilitating approach to clinical research for rare diseases in Radboudumc and beyond. You also contribute to the learning community that we will form on drug development for rare diseases and collaborate within the clinical drug development team with two pharmacists, a trial coordinator and trial support.

As an associated professor, you will advance clinical trial methodology for clinical trials in small populations. Jointly with the clinical expert teams you will design, help execute and analyze clinical trials in e.g., rare cancers, rare neurological, rare neuromuscular, rare sensory and rare kidney disorders. You will further develop the methodology for trials in rare diseases and personalized medicine, e.g., in platform trials, novel endpoints and analyses and/or Bayesian approaches.

Given the context and advanced nature of the clinical research, you will engage in grant proposals for clinical projects as well as develop methodological proposals. You will engage in teaching at BSc, MSc and post-graduate level, ensuring that relevant new developments find their place there. This may include contributions to new master or post-graduate level courses. You will strengthen research collaborations within Radboudumc, based on the advanced methodological expertise gained.

As associate professor Innovative Clinical Trial Design you will:
  • establish an overarching research line aiming at innovating and implementing methodology for clinical research in rare diseases, leveraging clinical trials, modelling and emerging real world data sources.
  • contribute to implementing a master track in therapy development and to teaching in the area of therapy development at bachelor, master and post-graduate level. 
  • lead and further build a research group, providing guidance to scientists with a focus on teaching, postdocs and PhDs and students from the various curricula of the Radboud(umc).
  • actively collaborate with Radboudumc researchers on therapy development for rare disorders.
  • acquire external competitive funding.
  • be part of Radboudumc and (inter-)national research consortia on therapy development for rare diseases.
  • contribute to policy making in rare disease therapy development.


Radboud University Medical Center (Radboudumc)


As an associate professor you will have:
  • a PhD degree in (bio-) statistics, mathematics or related field.
  • preferably a strong background in mathematics.
  • preferably proven experience in methodological and collaborative research during and after PhD.
  • a proven scientific interest in medical applications, e.g., through publications and collaborative projects, with specific focus on clinical research and clinical trials.
  • successful in developing novel research projects and obtaining research grants.
  • well-developed social skills directed to work in multidisciplinary and international teams.

Moreover, you fulfil the criteria of the Scientific Career Path policy, which include criteria of research quality, viability, impact, education and leadership. The position will lead to an Associate Professorship but depending on the experience and competence level of the candidate, the candidate may start as an Assistant Professor in Talent Track to associate professor.

This position will be assessed along the criteria for Assiociate Professor or for Assistant Professor in Talent Track to associate professor) as laid down in Radboudumc's scientific career path policy. This will include writing a personal performance and development plan including a reflection on leadership development as well as an interview with the Talent Track Committee.

Please upload a motivation letter, your curriculum vitae and the sectorplan application form that applies to your position. This form will guide you through some questions that are relevant for the selection.

Conditions of employment

Fixed-term contract: 1 year with a prospect to a permanent contract.

Working at Radboud university medical center means that you are ahead of the curve and working together on the healthcare of the future. And there is more. Our secondary terms of employment are impressive. These are fully tailored to you thanks to our Employment Conditions Selection Model. At Radboud university medical center, you will be given trust, and you will take the responsibility to handle everything together.
  • A gross monthly salary between € 6.288 and € 7.989 (scale 14) based on full-time employment.
  • From 1 November 2023 the wages will increase by 4%.
  • An annual vacation allowance of 8% and an end-of-year bonus of 8.3%.
  • If you work irregular hours, you will receive an allowance.
  • As a full-time employee (36 hours per week), you are entitled to approximately 168 vacation hours (over 23 days) per year.
  • Radboud university medical center pays 70% of the pension premium. You pay the rest of the premium with your gross salary.
  • You get a discount on health insurance as well: you can take advantage of two group health insurance plans. UMC Zorgverzekering and CZ collectief.
  • We provide annual courses, both professional and personal.

In addition to our terms of employment, we also offer employees various other attractive facilities, such as childcare and sports facilities. Want to learn more? Take a look at the CAO UMC.



As part of the team that will implement the goals of the ‘Sectorplan Medical Sciences’ you contribute directly to attaining the strategic research goals of Radboudumc in the area of therapy development for rare diseases. The sectorplan is structural funding of the ministry of education, culture, and science (OCW) to enhance research and education in medical and health sciences, including attractive working conditions (permanent contracts, lowering work pressure) and enhancing collaboration and profiling of the university medical centers.The sectorplan focuses on three main themes: Prevention, Data-driven innovation, and using fundamental research to have impact in the clinic.

The position is based within the section Biostatistics as part of the Science department (I.o.) IQ. It has a strong track record in statistical methodology for clinical research, with a focus on innovative designs and analysis of clinical research for personalized medicine rare disorders and (dynamic) prediction. The section is responsible for a substantial teaching portfolio in statistics for medical and biomedical students at BSc, MSc and postgraduate level. It has extensive joint projects with medical and research departments within the Radboudumc. The section has a longstanding collaboration with the Medicines Evaluation Board (CBG), thus acting at the forefront of drug development and regulation.

Radboud university medical center is a university medical center for patient care, scientific research, and education in Nijmegen. Radboud university medical center strives to be at the forefront of shaping the healthcare of the future. We do this in a person-centered and innovative way, and in close collaboration with our network. We want to have a significant impact on health and healthcare. We want to improve with each passing day, continuously working towards better healthcare, research, and education. And gaining a better understanding of how diseases arise and how we can prevent, treat, and cure them, day in and day out. This way, every patient always receives the best healthcare, now and in the future. Because that is why we do what we do.

Read more about our strategy and what working at Radboud university medical center means. Our colleagues would be happy to tell you about it. #weareradboudumc


  • Lecturer; Assistant professor; Associate professor; Professor; Research, development, innovation
  • Health
  • max. 36 hours per week
  • €6288—€7989 per month
  • University graduate
  • 184706-P1221137-1


Radboud University Medical Center (Radboudumc)

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Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen

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