The PhD project is part of the MODEM project. This is a Dutch multi-center study that will perform studies on the pathophysiology of Alzheimer's disease (AD) and frontotemporal lobe dementia (FTD) in order to find novel treatments. Previous studies on AD and FTD pathophysiology had the disadventage that data were analysed in isolation in different models (i.e., cell cultures, mouse models, and patients), with different modalities (genomics, proteomics, and lipidomics) and in different matrices (brain tissue, cerebrospinal fluid (CSF), plasma).
In MODEM, omics analyses will be performed in several disease models and in clinical patients in different matrices and with different omics techniques. The role of the PhD student is to bridge this clinical with fundamental research. You will organise, align and integrate large scale in-depth omics datasets from partners in the consortium.About your role
As a PhD candidate you will have the following responsibilities:
- Collaborate closely with partners in the MODEM consortium;
- Organise and align cross-species and multi-modal omics data;
- Develop and perform bioinformatic analyses;
- Write scientific articles, which will form the PhD thesis;
- Active participation to consortium and other scientific meetings, where you will also present your results.