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The School for Mental Health and Neuroscience (MHeNs) and the Institute for Technology-inspired Regenerative Medicine (MERLN) at Maastricht University in the Netherlands together with the BIOMED institute at Hasselt University in Belgium invite applications for a PhD position. The PhD student will perform cutting-edge research in computational modeling methods applied to cAMP signaling in the context of Alzheimer’s disease.
Nearly 50 million people worldwide suffer from Alzheimer’s disease (AD), the leading cause of dementia. The progression of AD coincides with neurodegeneration and memory loss. Only five treatments have been approved for AD therapy, all of which have limited efficacy and severe side effects, including nausea, vomiting, and even swelling of the brain. Thus, alternative drug targets within neuronal cells should be considered. At the subcellular level, we have previously shown that the second messenger cyclic adenosine monophosphate (cAMP) signaling is important to consolidate information into memory. In addition, an association was found between increased phosphodiesterase 4D (PDE4D) expression, a specific cAMPdegrading
enzyme, in the brain and greater decline of memory and thinking skills in AD, making PDEs promising drug targets. This research project aims to use an integrated in silico-in vitro methodology to identify the key PDE4 isoforms to target and improve current AD therapies.
What we offer:
Requirements and key expertise
Fixed-term contract: 1 + 3 years.
As a PhD Candidate at the Faculty of Health, Medicine and Life Sciences, you will be employed by the most international university of the Netherlands, located in the beautiful city of Maastricht. In addition, we offer you:
The terms of employment at Maastricht University are largely set out in the Collective Bargaining Agreement of Dutch Universities. In addition, local provisions specific to UM apply. For more information, Click here
Why work at Maastricht University?
At Maastricht University (UM), everything revolves around the future. The future of our students, as we work to equip them with a solid, broad-based foundation for the rest of their lives. And the future of society, as we seek solutions through our research to issues from all around the world. Our six faculties combined provide a comprehensive package of study programmes and research.
In our teaching, we use the Problem-Based Learning (PBL) method. Students work in small groups, looking for solutions to problems themselves. By discussing issues and working together to draw conclusions, formulate answers and present them to their peers, students develop essential skills for their future careers.
With over 22,300 students and more than 5,000 employees from all over the world, UM is home to a vibrant and inspiring international community.
Are you drawn to an international setting focused on education, science and scholarship? Are you keen to contribute however your skills and qualities allow? Our door is open to you! As a young European university, we value your talent and look forward to creating the future together.
Click here for more information about UM.
At the Faculty of Health, Medicine and Life Sciences (FHML), everything revolves around healthy living. Our research and education focuses not only on recovery, but also on prevention, health maintenance and health promotion. Our mission is to use our knowledge and expertise to bring about healthy lives for individuals and for society as a whole. FHML works closely in education, research and healthcare provision with the Maastricht academic hospital, together with which it forms the Maastricht University Medical Centre (MUMC+).
The largest faculty at Maastricht University, FHML is home to an international community of staff and students. We offer a wide range of Dutch- and English-taught bachelor’s and master’s programmes, using innovative educational concepts and building bridges to practice.
Research at FHML is multidisciplinary and revolves around select, topical themes. It encompasses the full spectrum, from fundamental research aiming to gain new insights to research whose results translate directly into concrete applications and innovations. The various research programmes are organised into our six graduate schools and two research institutes.
School for Mental Health and Neuroscience
The successful candidate will be a member of the division for Translational Neuroscience in the School of Mental Health and Neuroscience (MHeNs). This division has state-of-the-art laboratories for electrophysiology, microscopy, molecular biology, as well as biochemistry laboratories for tissue processing, cell culturing, immunohistochemistry, proteomics and genomics. Parts of the in vitro work of this joint initiative will be performed here. MHeNs has more than 300 PhD students and around 100 faculty members https://www.maastrichtuniversity.nl/research/mhens/about/divisions/division-3-translationalneuroscience
MERLN Institute for Technology-inspired Regenerative Medicine
The project is co-hosted by the department of Cell Biology-Inspired Tissue Engineering (cBITE) at the MERLN Institute for Technology-inspired Regenerative Medicine, which focuses on developing novel and challenging technologies to advance the field of tissue and organ repair and regeneration through, amongst others, the development of high-throughput material platforms to screen cell-biomaterial interactions. MERLN consists of an interdisciplinary team of researchers including fields as (stem cell) biology, materials engineering, chemistry, micro/nanofabrication, additive manufacturing, etc. https://www.maastrichtuniversity.nl/research/institute-technology-inspired-regenerative-medicine
BIOMED is a multidisciplinary institute at Hasselt University (B) that uses high-end technology to deliver novel insights in three main disease areas: immunology, neuroscience and cardiovascular disease. BIOMED aims to translate scientific discoveries into applications that contribute to a healthier society in line with
the civic ambition of Hasselt University. Moreover, BIOMED invests in academic excellence, regional and international positioning and strong partnerships with other academic institutes, the health sector and the life science industry.
Maastricht University (UM)
Universiteitssingel 40, 6229 ER, Maastricht
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