As a post-doctoral researcher, you are responsible for the design, planning and execution of experimental research of this research line using cell and animal models. You will co-supervise two PhD students working on this project, present findings at scientific meetings, and write manuscripts and grant proposals. Together with the PhD students and a biotechnician, you will conduct a proteomic analysis in a sepsis mouse model to identify pathways relevant to mitochondrial quality control (mtQC) in the kidney, factoring in age and sex. The identified pathways will be validated using CRISPR/Cas9 knock-down in a cell model of sepsis-AKI. Based on these findings, you will identify therapeutic targets using in silico analysis, followed by a targeted phenotypic screening to identify compounds able to modulate these targets to induce mitochondrial recovery. You will closely collaborate with experts from the Emergency Department, Internal Medicine, Intensive Care Unit (UMCG), Clinical Sciences, Infection Medicine (Lund University, Sweden), and Anesthesiology and Intensive Care Medicine (University of Münster, Germany), as well as with private partners (Sulfateq BV)

You are a creative and enthusiastic researcher with a PhD-degree in life sciences, such as molecular/medical biology, biomedical or pharmaceutical sciences and are licensed to conduct animal experiments. You are a team player with excellent project management skills and extensive “wet lab” experience – including cell culture and animal experiments. You have good writing and data visualization skills as evidenced by your publication list and preferably previously obtained grants. You are interested in translational biomedical research, pre-clinical experiments, and drug discovery. Proficiency in one of the following areas is a prerequisite: -omics data analysis, CRISPR-Cas9 gene editing or disease models in C. elegans. Good social and communicative skills, team spirit, creativity, and intelligence are essential. The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.

This is a three-year full-time 36 hours appointment starting from November 1st (negotiable). Your salary will be a maximum of € 5.088,- gross per month (scale 10), depending on your qualifications and relevant experience, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Genetica

The UMCG is one of the largest hospitals in the Netherlands and takes care of an adherence region of > 2.5 million inhabitants in the north of the Netherlands. As a post-doctoral researcher, you will be appointed to the Department of Clinical Pharmacy & Pharmacology, section Experimental Pharmacology and embedded in the Early Sepsis research line (www.sepsisresearch.nl). The department conducts high-quality translational research to understand disease mechanisms, identify novel therapeutic targets, and develop drug interventions. The multidisciplinary group focuses on mitochondria as therapeutic targets in acute and chronic diseases. Post-doctoral researchers are enrolled in the UMCG Postdoc Council. Since its foundation in 1614, the University of Groningen (RUG) has enjoyed an international reputation as a dynamic and innovative center of higher education, offering high-quality teaching and research. Belonging to the best research universities in Europe and joining forces with prestigious partner universities and networks, the University of Groningen is truly an international place of knowledge. Groningen is a thriving university city set in quiet, spacious surroundings.