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T cell dysfunction is a key problem in cancer, enabling not only tumorigenesis but also causing resistance to immunotherapy. A better mechanistic understanding is imperative for improving immunotherapy. We recently received an ERC Advanced grant for “ReverT”, a function-based genetic CRISPR-Cas9 screening program to identify genes, ablation of which reverses T cell dysfunction in vivo. This will be done in a pooled and multimodal fashion, analyzing multiple dysfunction phenotypes in parallel, like immune checkpoints, exhaustion, metabolism, recruitment and proliferation. We have already identified several exciting candidates, including “nodal” factors, operating in several seemingly different dysfunction settings. We will use a collection of ex patient tumor models for validation and mechanistic characterization. Lastly, we will translate our findings to a preclinical setting, aiming to achieve more durable clinical responses.
An ambitious postdoctoral fellow in immunology We seek a highly ambitious postdoc with a strong background in immunology and an interest in fundamental and translational cancer research. Your responsibilities will include writing of manuscripts and grant applications. Proficiency in English and good communicative skills are important requirements, as is a team player mentality.
Fixed-term contract: 2 years, with the possibiltiy for extension.
You will be employed for a minimum period of 2 years, with the possibiltiy for extension. The gross salary per month is € 3.695,- to € 4.391,- according to salary scale FWG 55, depending on your experience. The terms of employment will be in accordance with the CAO Hospitals and includes an end-of-year bonus and holiday pay. Acquisition for this vacancy is not appreciated.
The Netherlands Cancer Institute (NKI) Located in Amsterdam, NKI is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many advanced core facilities, including flow cytometry, proteomics, genomics, biobank and a mouse cancer center.
Today's research for tomorrow's cure
The Netherlands Cancer Institute is among the world’s best comprehensive cancer centers, combining innovative fundamental, translational, and clinical research with dedicated patient care. Our research institute gratefully acknowledges funding from the Dutch Ministry of Health, Welfare and Sport, the Dutch Cancer Society, and individual donors.
The Netherlands Cancer Institute
Plesmanlaan 121, 1066 CX, Amsterdam
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