Postdoc vacancy in Peeper Lab for ERC Advanced project

Postdoc vacancy in Peeper Lab for ERC Advanced project

Published Deadline Location
31 Dec 5 Apr Amsterdam
Reversing T cell dysfunction in cancer by multimodal genetic screening

Job description

Project information

T cell dysfunction is a key problem in cancer, enabling not only tumorigenesis but also causing resistance to immunotherapy. A better mechanistic understanding is imperative for improving immunotherapy. We recently received an ERC Advanced grant for “ReverT”, a function-based genetic CRISPR-Cas9 screening program to identify genes, ablation of which reverses T cell dysfunction in vivo. This will be done in a pooled and multimodal fashion, analyzing multiple dysfunction phenotypes in parallel, like immune checkpoints, exhaustion, metabolism, recruitment and proliferation. We have already identified several exciting candidates, including “nodal” factors, operating in several seemingly different dysfunction settings. We will use a collection of ex patient tumor models for validation and mechanistic characterization. Lastly, we will translate our findings to a preclinical setting, aiming to achieve more durable clinical responses.

Specifications

The Netherlands Cancer Institute

Requirements

An ambitious postdoctoral fellow in immunology We seek a highly ambitious postdoc with a strong background in immunology and an interest in fundamental and translational cancer research. Your responsibilities will include writing of manuscripts and grant applications. Proficiency in English and good communicative skills are important requirements, as is a team player mentality. 

Conditions of employment

Fixed-term contract: 2 years, with the possibiltiy for extension.

You will be employed for a minimum period of 2 years, with the possibiltiy for extension. The gross salary per month is € 3.695,- to € 4.391,- according to salary scale FWG 55, depending on your experience. The terms of employment will be in accordance with the CAO Hospitals and includes an end-of-year bonus and holiday pay. Acquisition for this vacancy is not appreciated.

Employer

The Netherlands Cancer Institute (NKI) Located in Amsterdam, NKI is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many advanced core facilities, including flow cytometry, proteomics, genomics, biobank and a mouse cancer center.

Today's research for tomorrow's cure

The Netherlands Cancer Institute is among the world’s best comprehensive cancer centers, combining innovative fundamental, translational, and clinical research with dedicated patient care. Our research institute gratefully acknowledges funding from the Dutch Ministry of Health, Welfare and Sport, the Dutch Cancer Society, and individual donors.

Additional information

Interested
For further information and addresses visit our websites: https://www.nki.nl/research/research-groups/daniel-peeper/
Applications can be submitted via the application button and should include your CV, a motivation letter and the contact information of your references (in your letter of interest). 

More information

Select reading 

  • Zhang et al, RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells, Cell Reports Medicine 2022
  • Apriamashvili et al, Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling, Nature Comm 2022
  • Krijgsman et al, Predictive immune-checkpoint blockade classifiers identify tumors responding to inhibition of PD-1 and/or CTLA-4, Clin Cancer Res 2021
  • Vredevoogd et al., Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold, Cell 2019

The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.

Acquisition for this vacancy is not appreciated.

Specifications

  • Postdoc; Research, development, innovation
  • Health
  • max. 36 hours per week
  • €3695—€4391 per month
  • Doctorate
  • PA NKI 20231005-1

Employer

The Netherlands Cancer Institute

Learn more about this employer

Location

Plesmanlaan 121, 1066 CX, Amsterdam

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Application procedure

Interested
For further information and addresses visit our websites: https://www.nki.nl/research/research-groups/daniel-peeper/
Applications can be submitted via the application button and should include your CV, a motivation letter and the contact information of your references (in your letter of interest). 

The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.

Acquisition for this vacancy is not appreciated.

Application procedure

Application procedure

Interested
For further information and addresses visit our websites: https://www.nki.nl/research/research-groups/daniel-peeper/
Applications can be submitted via the application button and should include your CV, a motivation letter and the contact information of your references (in your letter of interest). 

The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.

Acquisition for this vacancy is not appreciated.

Make sure to apply no later than 5 Apr 2024 23:59 (Europe/Amsterdam).