Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy (predicted to become the second leading cause of cancer-related deaths by 2030), with a limited number of diagnostics tools, nor effective systemic treatments.

Microbiome has emerged as a cause of the remarkable chemoresistance of PDAC. The clinical relevance of microbiome in PDAC was demonstrated by the relationship between intra-tumoral bacterial diversity and specific microbiome profiles in comparing long- and short-term survivors. We hypothesize that tumor and microbial composition yield complementary molecular mechanisms underlying drug resistance.

The PhD candidate will conduct research to understand the microbiome-induced chemoresistance and develop effective therapeutics to interfere with host-PDAC-microbiome interactions.

Project-related tasks include:

• In vitro microbiological experiments with aerobic and/or anaerobic bacteria
• In vitro experiments on the interactions between microbes and host cells
• Imaging and omics analysis of in vitro microbe-host interaction and in situ samples
• Data analyses and preparation of scientific publications
• Co-supervision of trainees and students

• A MSc degree (or equivalent) in Biology/Ecology/Biochemistry/Biomedicine or a related field.
• Previous experience with microbiological culture/cell culture and imaging as well as affinity with modern molecular biology and next-generation techniques is an advantage.
• Strong commitment, interest in working with drugs and desire to translate your results into the clinic are recommended.
• Able to work not only independently but also in an international multi-disciplinary research team.
• Self-motivation, scientific creativity and curiosity are essential.
• Good organization skills and excellent English communication and writing skills ability.

• You will be employed for an initial period of 12 months, after which your performance will be evaluated. If the evaluation is positive, the contract will be extended by 3 years (4-year contract).
• Salary scale OIO : € 2,789- € 3,536 gross, based on 36 hours/week. The monthly wage will increase yearly to the maximum wage in the fourth year.
• Effective of November 2023, a 4% salary increase will occur.

In addition we offer:

• An 8.3% end-of-year bonus and 8% holiday pay. Bereken hier jouw netto salaris.
• Free and unlimited access to our online learning environment: GoodHabitz.
• Pension is accrued at the ABP. Amsterdam UMC contributes 70% of the premium.
• We reimburse 75% of you public transport commuting costs. Would you rather bike? We have a good bike arrangement in place.
• You can choose to participate in the active staff association, as well as the Young Amsterdam UMC association, which both organize fun activities and events.

Amsterdam UMC

The successful PhD candidate will work in a multidisciplinary team including microbiologists, molecular and cell biologists, pharmacologists, biostatisticians and clinicians.

You will be part of a welcoming and international community that values your contributions, encourages collaboration, and provides a supportive environment for your research endeavors.