PhD Candidate Correlative Super-resolution microscopy of mRNA nanoparticles

PhD Candidate Correlative Super-resolution microscopy of mRNA nanoparticles

Published Deadline Location
14 Dec 29 Feb Eindhoven
Are you passionate about microscopy? We are searching for a young scientist use advanced optical microscopy techniques such as super-resolution microscopy and correlative light-electron microscopy to study mRNA nanoparticles.

Job description

Oligonucleotides such as messenger RNAs hold great promise as therapeutics in a vast number of diseases, ranging from genetic defects to cancer and infectious diseases. However, efficient oligonucleotide delivery is one of the most burning problems in biomedicine. At present we lack understanding of the structure of oligonucleotide delivery vectors, their interactions with cells and intracellular trafficking, and of their behavior in complex tissue environments.
The aim of this project is to develop super-resolution microscopy and correlative imaging workflows that will enable to paint the complete dynamic and ultrastructural picture of oligonucleotide delivery in cells and tissues. These workflows will provide a seamless integration of super-resolution microscopy (SMLM, STED), and electron microscopy (FIB/SEM and cryo-TEM) and will be used to relate ultrastructural information to the chemistry of delivery complexes, how it evolves during uptake and how this correlates with activity.

This four-year project is a collaborative effort between the Nanoscopy for Nanomedicine group led by Lorenzo Albertazzi https://www.tue.nl/en/research/research-groups/nanoscopy-for-nanomedicine/ and the department of Medical BioSciences (Prof. Dr. Roland Brock/Prof. Dr. Nico Sommerdijk) at Radboud University. The project is funded through the 'Open Technology Program' of the Dutch Science Organization NWO and is supported by four companies in the area of  microscopy and messenger RNA formulation and clinical application.

Specifications

Eindhoven University of Technology (TU/e)

Requirements

  • Master in Biophysics, physical chemistry, biomedical engineering, chemical biology nanotechnology or a comparable domain.
  • Ability to conduct high quality academic research, demonstrated for instance by a relevant Master thesis and/or publication(s).
  • Excellent mastering of the English language, good communication and leadership skills. Note that there is no Dutch language requirement.
  • Experience with nanoparticle imaging and super-resolution microscopy is an asset

Conditions of employment

A meaningful job in a dynamic and ambitious university, in an interdisciplinary setting and within an international network. You will work on a beautiful, green campus within walking distance of the central train station. In addition, we offer you:
  • Full-time employment for four years, with an intermediate evaluation (go/no-go) after nine months. You will spend 10% of your employment on teaching tasks.
  • Salary and benefits (such as a pension scheme, paid pregnancy and maternity leave, partially paid parental leave) in accordance with the Collective Labour Agreement for Dutch Universities, scale P (min. €2,770 max. €3,539).
  • A year-end bonus of 8.3% and annual vacation pay of 8%.
  • High-quality training programs and other support to grow into a self-aware, autonomous scientific researcher. At TU/e we challenge you to take charge of your own learning process.
  • An excellent technical infrastructure, on-campus children's day care and sports facilities.
  • An allowance for commuting, working from home and internet costs.
  • A Staff Immigration Team and a tax compensation scheme (the 30% facility) for international candidates.

Additional information

About us

Eindhoven University of Technology is an internationally top-ranking university in the Netherlands that combines scientific curiosity with a hands-on attitude. Our spirit of collaboration translates into an open culture and a top-five position in collaborating with advanced industries. Fundamental knowledge enables us to design solutions for the highly complex problems of today and tomorrow. 

Curious to hear more about what it's like as a PhD candidate at TU/e? Please view the video.

Information

Do you recognize yourself in this profile and would you like to know more?Please contact the hiring manager Lorenzo Albertazzi, l.albertazzi[at]tue.nl.

Visit our website for more information about the application process or the conditions of employment. You can also contact Sascha Sanchez, HR advisor, s.j.m.g.sanchez.van.oort[at]tue.nl or +31 40 247 7310.

Are you inspired and would like to know more about working at TU/e? Please visit our career page.

Application

We invite you to submit a complete application by using the apply button.
The application should include a:
  • Cover letter in which you describe your motivation and qualifications for the position.
  • Curriculum vitae, including a list of your publications and the contact information of three references.
     

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Specifications

  • PhD
  • Engineering
  • max. 38 hours per week
  • University graduate
  • V50.7139

Employer

Eindhoven University of Technology (TU/e)

Learn more about this employer

Location

De Rondom 70, 5612 AP, Eindhoven

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Application procedure

Application procedure

Make sure to apply no later than 29 Feb 2024 23:59 (Europe/Amsterdam).