Research focus

We welcome applications from researchers with a passion for pediatric liver tumors, including hepatoblastoma and hepatocellular carcinoma (HCC), as well as rare metabolic liver diseases in children. Our aim is to understand the molecular profiles of these diseases and to create innovative therapeutic strategies based on these insights.

Innovative Techniques and Collaborative Environment

As a member of our team, you will utilize advanced methodologies such as single-cell and spatial transcriptomics, high-throughput screening, RNA therapy, and antibody engineering. Organoid and mouse models will be used to further our understanding of these treatment modalities. Collaborations with the Single Cell Genomics Facility, Protein and Antibody Facility, High Throughput Screening Facility, and Big Data Core are key to our research, providing a stimulating environment for scientific discovery and progress. Our extensive collaborations both within the Utrecht Science Park and with international institutions foster a dynamic and interdisciplinary research environment. We will align the specific research focus with the postdoctoral researcher’s interests and areas of expertise to ensure a rewarding and mutually beneficial experience.

• A PhD in life sciences or a related discipline.
• Expertise in one or more of the following areas: single-cell and spatial analysis, organoid methodology, structural biology, antibody development, liver biology, or immunology.
• A robust publication record in renowned journals.
• Demonstrated motivation, creativity, and strong analytical skills.

Fixed-term contract: 1 year, with a possible extension.

We provide a full-time position (36 hours) in a stimulating research environment with ample opportunities for professional development.  You will initially be appointed for the duration of one year, with a possible extension. Your gross monthly salary will depend on your experience and background, starting in scale 60 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

The Princess Máxima Center

The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

The Peng Lab

Our focus is on childhood liver cancer, related diseases, and regenerative medicine. Our goal is to unravel the molecular mechanisms that drive childhood liver cancer and to develop innovative therapeutic approaches. We have previously pioneered the method for 3D hepatocyte organoid culture, and we will continue to leverage this organoid technology to model diseases for therapeutic discovery.