At the Laboratory of Hematology, section of Thrombosis and Hemostasis, we are focusing on coagulation disorders. Hemostasis is a complex and tightly regulated system, and a disbalance in this system can cause thrombosis on one side, whereas bleeding can occur on the other. The relevance of a functional hemostatic system is reflected in the fact that hemorrhage following trauma is one of the most important causes of death under the age of 46 years, whereas thrombosis related diseases are the general leading cause of mortality, incidence increasing with age.
Correct diagnosis of a bleeding or prothrombotic tendency forms an important hurdle in clinical practice. In approximately 50% of the patients with a bleeding diathesis and even a larger percentage of people with a history of thrombosis, a causal aberrance in hemostasis cannot be identified, even after extensive laboratory and genetic testing. As a PhD candidate you will contribute to this fundamental question by identifying and characterizing novel causal variants in patients with unexplained bleeding or thrombotic tendency using state of art genetic, molecular and biochemical techniques.
Furthermore, during treatment of hemostatic disorders with novel anti- and procoagulant medication, indication for testing, opportunities for rapid testing and validation of technical performance as well as clinical validation in specific patient populations has been explored to a limited extent. The PhD candidate will focus on these directly clinically relevant aspects as well. Our research aims to span the entire field from fundamental research to applied science with direct impact for individual patients, which is strongly reflected in this project.Tasks and responsibilities
- Genomic/ transcriptomic/ proteomic analysis.
- Functional analysis of identified genes/ proteins.
- Conducting systematic searches in literature databases.
- Validation of laboratory tests.
- Writing scientific publications for international journals.
- Presenting results at (scientific) meetings.
- Collaborating with supervisors, internal and external partners.
All these tasks are aimed at obtaining an academic PhD. In addition, PhD students contribute to general activities taking place within the laboratory of hematology and within the research institute.