Postdoc 'Identify master regulators of B-cell membrane targets to improve immunotherapy of non-Hodgkin lymphoma'

Postdoc 'Identify master regulators of B-cell membrane targets to improve immunotherapy of non-Hodgkin lymphoma'

Published Deadline Location
8 Feb yesterday Nijmegen

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Job description

We are looking for an ambitious postdoctoral researcher to investigate key regulators of CD20, CD22, and CD37 expression in B-cell non-Hodgkin lymphoma, aiming to enhance antibody-based therapies for improved treatment outcomes. Are you ready to think further for our patients and our care?

B-cell non-Hodgkin lymphoma (B-NHL), the most common hematological malignancy worldwide, still remains a clinical problem. Immunotherapy with rituximab, which targets CD20, is a cornerstone drug in the treatment of many B-NHL patients, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL). However, decreased expression levels of membrane targets (CD20, CD22, CD37) in B-NHL is related to refractory/relapsed disease and poor prognosis.

The aim of this project is to define key regulators that control expression of CD20, CD22 and CD37 at the surface of malignant B cells, and to identify compounds that increase target molecule availability to increase the impact of antibody-based treatment in B-NHL. We will combine unbiased genetic and compound screens, and a candidate-based approach with antibody-based therapy in human B-NHL cell lines, primary DLBCL and CLL patient samples and lymphoma mouse models.

This research will provide molecular and biological insight into the underlying mechanisms of antibody resistance, and improve antibody-based treatment outcome in B-NHL patients.

Specifications

Radboud University Medical Center (Radboudumc)

Requirements

You are a creative and motivated researcher with a PhD degree in biomedical sciences/ molecular biology (or equivalent). You will set-up CRISPR/Cas9 screens in B-NHL cells to identify key regulators of CD20/CD22/CD37 in collaboration with the Dutch Cancer Institute (NKI).

Novel candidates will be validated in lymphoma cytotoxicity assays, B-NHL patient tissues and in vivo lymphoma models. Experience with molecular biology and cell biological techniques is a must. A permit to work with animals (or willing to obtain this) is an advantage.

Conditions of employment

Fixed-term contract: 1 year with a possible extension.

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:
  • A gross monthly salary in scale 10 between € 3.359 and € 5.292 (for a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
  • Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment. You can also share knowledge with colleagues through digital learning spaces – perfect for getting inspired and inspiring others.
  • Your well-being and vitality are our priorities. For instance, you can enjoy a 40% discount on a sports subscription at the Radboud Sports Center along with access to the Healthy Professionals program designed to assist you in managing your energy. If you are going through a life-changing event, our Company Support Team and a personal coach are there to help you.
  • If you are going through a life-changing event, our Company Support Team and a personal coach are there to help you.
  • Support in achieving a good work-life balance at every stage of your life. This includes advice and training courses (from ‘Millennial Dilemmas’ to ‘Your Career After 57’), activities at our own mindfulness center, and informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
  • 168 holiday hours per year (23 days) based on a 36-hour working week.
  • 26 weeks of parental leave, nine of which are paid.
  • You build up a pension by ABP Pension Fund, and Radboudumc pays 70% of the pension premium.
  • Discounts on health insurance and ten other types of insurance, from home insurance to legal assistance.
  • An allowance for your travel expenses or a working-from-home allowance of €2 per day.

Employer

Radboudumc

The department of Medical BioSciences aims at a better understanding of our immune system using molecular-, cell biological- and immunological- techniques and is centered around dendritic cells and lymphocytes which are key cells in anti-tumor immunity. Our multi-disciplinary Department combines fundamental with translational research, including different clinical trials of dendritic cell immunotherapy in cancer patients.

We are embedded within the Radboud University Medical Center that provides an outstanding, multi-cultural and thriving research setting through technology platforms such as genomics, proteomics and advanced imaging.

Radboudumc
Welcome to Radboud university medical center (Radboudumc), where our research groups strive for innovative solutions that make impact on health and healthcare. We challenge the status quo to overcome current and future health challenges. Our goal is to shape the future of healthcare for generations to come. Our focus is on prevention, sustainability, and meaningful care, which we achieve through our in-depth understanding of disease mechanisms, clinical science, public health research, medical technology and data science. Our approach is centered on breakthroughs that can truly enhance personalized healthcare and public health.

At Radboudumc, a comprehensive range of research programs provide the compass for our research efforts. Each program has a clear goal, where collaboration within and outside our organization is highly valued. We integrate care, education and research in partnership with our patients to ensure that our research programs have significant impact on health and healthcare. We invite you to join us in our mission to create a healthy future for all.

Specifications

  • Postdoc; Research, development, innovation
  • Natural sciences; Health
  • max. 36 hours per week
  • €3359—€5292 per month
  • University graduate
  • 190429-P1428840-1

Employer

Radboud University Medical Center (Radboudumc)

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Location

Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen

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