Are you interested in unraveling the underlying mechanisms causing leukemia and keen to further develop our understanding of leukemia biology in order to ultimately improve patient care? We currently have a PhD position available at the Department of Hematology in the UMCG, focusing on the molecular mechanisms in nucleophosmin (NPM1) mutated acute myeloid leukemia.

The current project is funded by the Dutch Cancer Society and aims to dissect the pathogenesis of NPM1-mutated AML, in order to ultimately improve therapy. NPM1 is one of the most frequently
mutated gene in AML. While the clinical relevance of NPM1 mutations in AML is well established, the biological mechanisms by which NPM1 mutations exert their oncogenic functions are poorly understood. We will investigate the effect of NPM1 mutations on the process of protein translation, using polysome profiling studies and RNA sequencing. Further, altered nuclear transport processes and protein quality control mechanisms in NPM1 mutated AML will be subject to our investigations, using patient-derived AML cell cultures and detailed molecular studies.

- MSc degree in biomedical/life-sciences related subject
- Excellent English writing and presenting skills
- A strong team player, but also the ability to work independently
- Experience in cell biological techniques (e.g. eukaryotic tissue culture) is required
- Experience in molecular biology techniques such as Western Blotting, molecular cloning, retroviral/lentiviral transduction protocols, sequencing is desirable
- You are highly motivated and eager to advance our understanding of leukemia

The UMCG has a preventive Hepatitis B policy.

- A fulltime contract for 1 year, which will be extended for 3 years after evaluation
- A salary of € 2.901,- in the first year to a maximum of € 3.677,- gross per month in the final year (PhD salary scale), based on a fulltime contract
- A holiday allowance of 8% gross annual income and an 8.3% end of the year bonus
- The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Hematologie

You will be part of a young and enthusiastic research group at the department of Hematology, UMCG. The research project forms a new research line within this department led by dr. C.M. Woolthuis. The work will be embedded within the research group of prof. dr. J.J. Schuringa and prof. dr. G. Huls.

https://www.experimentalhematology-schuringalab.nl