PhD student Proteomics in Hemostasis

PhD student Proteomics in Hemostasis

Published Deadline Location
17 Apr 14 Jun Amsterdam

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Clinical proteomics in hemostatic disorders

Congenital and acquired disorders of hemostasis represent a large clinical burden. The mission of the Medical Priority Bleeding & Hemostasis of Sanquin Research is to improve diagnosis and treatment of patients suffering from acquired and genetic bleeding disorders. We are looking for a PhD student, a bio-informatician/post-doc and a technician to join our rapidly expanding team that focuses on mass spectrometry-based approaches to unravel hemostatic disorders.

Job description

PhD student

In this PhD project, we aim to advance the molecular understanding of pathogenic mechanisms in patients with rare or undefined hemostatic disorders. We will tackle this at the system-wide level using PRM-based targeted proteomics, DIA-based global plasma profiling and proteogenomic-based variant analysis. For this highly innovative project, we especially encourage applications of talented researchers with the skills and ambition to integrate clinical and ‘omics’-based profiling data with the ultimate goal to identify and study novel pathogenic mechanism in patients with hemostatic disorders.

Medical Priority Bleeding and Hemostasis

The medical priority Bleeding and Hemostasis is an international frontrunner in applying state-of-the-art mass spectrometry-based proteomics in the area of benign hematology. We are a vibrant, international group of 35-40 colleagues (consisting of group leaders, postdocs, PhD students and technicians) that study the various aspects of hemostatic networks. Our department has academic affiliations with high-ranking universities in the Netherlands, such as Utrecht University and the University of Amsterdam. The department’s research program benefits from excellent research facilities, which include the latest technology for biomolecular mass spectrometry, imaging and cell sorting.

Specifications

Sanquin Blood Supply Foundation (Sanquin)

Requirements

Requirements for the PhD position 

  • A MSc degree in analytical chemistry, biology, (bio)molecular/biomedical/pharmaceutical sciences or equivalent.  Pro-active and eager to learn and employ a variety of biochemistry assays and quantitative proteomics to address research questions. Affinity with bioinformatics and data analysis, reporting and visualization.
  • Problem-solving skills and capability to apply knowledge and experience to address complex challenges
  • Good communication skills in English
  • The ability to work efficiently independently, but also in close collaboration with a multidisciplinary and international team composed of highly ambitious young researchers.

Conditions of employment

Fixed-term contract: 4 years.

Conditions of employment

We offer unique research opportunities in a dynamic environment. Nowhere else in the world you will find an organization that combines medical, pharmaceutical, diagnostic and scientific research under one roof.  In addition to a challenging project in a multi-disciplinary and enthusiastic team we offer:

  • Salary and working conditions conform CAO Sanquin;
  • Temporary position for the duration of 4 years (PhD student)
  • A full time contract of 36 hours per week;
  • 8,33% end-of-year bonus;
  • 8,33% holiday allowance;
  • Partial reimbursement of travel expenses;
  • Pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
  • Collective discounts on various insurances;
  • At fulltime employment (36 hours) 201 hours of leave per annum

Learn more about our terms of employment at https://www.sanquin.org/working-at/who-we-are/employment-conditions.

Specifications

  • Postdoc; Research, development, innovation
  • Health; Food; Natural sciences
  • max. 36 hours per week
  • University graduate
  • AT SANQUIN 20241704-2

Employer

Sanquin Blood Supply Foundation (Sanquin)

Learn more about this employer

Location

Plesmanlaan 125, 1066 CX, Amsterdam

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