The prevalence of obesity has increased worldwide and is associated with major health problems such as type II diabetes and cardiovascular disease. Metabolic homeostasis is regulated differently between males and females. Sex steroid hormones are major factors that can explain this sex dimorphism, as they contribute to sex differences in body fat distribution and insulin sensitivity. High androgen levels in women (for example in polycystic ovary syndrome (PCOS), and low androgen levels in men (for example in late-onset hypogonadism) both lead to obesity and increased risk of diabetes. The drop in estrogen levels in women entering menopause is considered the driving factor for the significant increased risk of obesity in postmenopausal women. The current research project aims at understanding the molecular mechanisms underlying the sex-specific effects of sex steroid hormones in obesity. The project will combine in vitro and in vivo experiments using mouse models and in vitro experiments using human adipocyte cultures.

We are seeking candidates who are highly motivated and career-oriented with a strong background and track record in metabolism and molecular or cellular biology. A background in ChIP-sequencing, RNA-seq and bioinformatics is a definite asset as well as experience with mouse studies (art.9 certified). Your expertise is demonstrated by an excellent publication record in a relevant research field. You have excellent communication and writing skills. You are capable to work in a multidisciplinary team. The applicant must have a PhD in a Biology or a related field with less than five year experience as post-doctoral fellow.

Being able to present a certificate of good conduct is a condition for the appointment.

The gross monthly salary amounts a maximum of € 4.917,- (scale 11), depending on your level of education and relevant experience and based on a full-time working week of 36 hours. The terms of employment are in accordance with the Collective Bargaining Agreement for University Medical Centers (CAO UMC).

Erasmus MC

Erasmus MC stands for a healthy population and excellence in healthcare through research and education. This is achieved through conducting groundbreaking work, that pushes boundaries and leads the way in research, education, and healthcare. We are skilled people with a high level of expertise and, hard working to improve and renew healthcare of today and public health of tomorrow.

The Department of Internal Medicine is a large department with several research groups. The research group "Metabolism and Reproduction" focuses on aspects of metabolic differences between men and women in health and disease. We approach our research questions using physiological and cellular techniques, both in animal models and in humans. An important principle that guides our efforts is the possibility to apply our findings in the clinic and, vice versa, paying attention to questions that arise in the clinic when treating patients.

You will be a member of a team that consists of PhD students, basic scientists and clinical scientists.