PhD Single-molecule and super-resolution imaging of catalytic nanoparticles

PhD Single-molecule and super-resolution imaging of catalytic nanoparticles

Published Deadline Location
14 Nov 31 Jan Eindhoven

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The Eindhoven University of Technology (TU/e) has the following vacancy: PhD in super resolution microscopy of drug delivery nanoparticles within the department of Biomedical Engineering (BME), under the Marie Sklodowska-Curie Early Stage Researcher programme.

Job description

The Laboratory of Molecular Biosensing at the TU Eindhoven is looking for an Early Stage Researcher (PhD student) to develop her/his PhD thesis project on the single-molecule and super-resolution imaging of catalytic nanoparticles. We are searching for a young scientist who is interested to combine advance optical microscopy and nanotechnology. The contract will be within the framework of the Marie Skłodowska-Curie European Training Network THERACAT, whose objective is to train a new generation of early stage researchers in innovative topic of bio-orthogonal catalysis for cancer therapy. THERACAT is an international and multidisciplinary consortium comprising 6 academic partners from top European institutions, 3 industrial partners active in the pharmaceutical market, and a partner focusing on science communication. You will learn to use super-resolution microscopy and apply it to study the structure and behavior of catalytic nanoparticles with potential use in cancer therapy.

About Eindhoven University of Technology (TU/e):
The TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. The TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.

About the Department of Biomedical Engineering (BME):
The Department of Biomedical Engineering offers a research driven BME Bachelor program and Masters Biomedical Engineering, Medical Sciences and Technology and Medical Engineering in its Graduate Program. Research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modeling. The department has more than 800 students and up to 200 tenured and non-tenured employees.

About the Institute for Complex Molecular Systems (ICMS):
The Institute for Complex Molecular Systems is an interdisciplinary institute at Eindhoven University of Technology (TU/e) which brings excellent researchers from different areas together to promote cross-breeding of ideas across disciplines in the departments Biomedical Engineering, Applied Physics, Chemical Engineering and Chemistry, Mathematics and Computer Science, and Mechanical Engineering. The institute aims to create and study biologically relevant functional structures with the ultimate goal of understanding the complexity of life.

About Molecular Biosensing:
The Molecular Biosensing group (MBx, see www.tue.nl/mbx) aims at creating ideas and generating scientific insights in the area of molecular biosensing technologies. This involves the engineering of molecular constructs for sensing applications (using protein, nucleic-acid, and protein-DNA technologies), methods to biofunctionalize nanoparticles, methods to characterize particle behavior in complex environments, the development of novel single-molecule measurement methods, optical microscopies, particle characterization techniques, plasmonic effects, particle actuation principles, signal processing, and simulations. The group develops technologies to detect proteins and study protein function with single-molecule sensitivity in complex macromolecular environments. The research leads to novel methods for molecular biosensing, insights into protein function within complex and crowded environments, and novel routes into point-of-care and patient monitoring applications. Laboratories are shared with the Chemical Biology research group of the Department of Biomedical Engineering (www.tue.nl/cb) and the Institute for Complex Molecular Systems (www.tue.nl/icms).

Specifications

Eindhoven University of Technology (TU/e)

Requirements

We are looking for enthusiastic candidates who are in an MSc program or who already have an MSc degree, preferably in Physics, Biophysics, Physical Chemistry or Biomedical Engineering. An interest in microscopy is required. Experience with optical spectroscopy or microscopy is required. Additional experience with single-molecule measurements would be an asset. 
Marie-Curie Fellowship Mobility Requirement: At the time of recruitment by the TU/e, the candidate must not have resided or carried out their main activity (work or studies) in the Netherlands for more than 12 months in the 3 years immediately prior to their recruitment.

Conditions of employment

We offer:
  • A challenging job at a dynamic and ambitious University and in an enthusiastic team.
  • An appointment (1 fte) as a PhD-student for four years, starting date: flexible, but preferably as soon as possible.
  • Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from € 2266 per month initially, to € 2897 in the fourth year.
  • An attractive package of fringe benefits, including excellent work facilities, end of the year allowance and sports facilities.
  • Specifications

    • PhD
    • Engineering
    • max. 38 hours per week
    • University graduate
    • V50.3590

    Employer

    Eindhoven University of Technology (TU/e)

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    Location

    De Rondom 70, 5612 AP, Eindhoven

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