PhD candidate 'Cancer immunotherapy and chemical tumor cell targeting'

PhD candidate 'Cancer immunotherapy and chemical tumor cell targeting'

Published Deadline Location
20 Feb 12 Mar Nijmegen

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Job description

A PhD training position on cancer immunotherapy and chemical tumor cell targeting is immediately available in the laboratory of Peter Friedl, MD, PhD, in the Department of Cell Biology, Radboud Institute of Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

The project is funded by the national NWO-Priority program "Institute for Chemical Immunology". We aim to investigate how the glycocalyx of tumor cells induces resistance to T cell-mediated killing and how this can be exploited for improving immunotherapy. We will collaborate with the team of Prof. Floris van Delft, Wageningen University, to develop and apply novel click chemistry to render the tumor cell more vulnerable and improve cytotoxic T cell function in the tumor microenvironment.

Please refer to our recent publications for related information on tumor targeting and the microenvironment (Nat Cell Biol 22:97, 2020; J Exp Med 217:e20181184, 2020; J Natl Cancer Inst 111:1042, 2019; Nat Cell Biol. 20:8, 2018; Nat Biomed Eng. 1:0007, 2017; Proc Natl Acad Sci USA. 112:7551, 2015).

Specifications

Radboud University Medical Center (Radboudumc)

Requirements

You have a M.Sc. in immunology, cancer biology, molecular biology, and/or microscopy and an interest in tumor immunology, molecular cell biology and quantitative microscopy. You will coordinate and conduct experiments and design research projects in the areas of cancer biology and immunology in 3D organotypic culture models and in animals, including intravital multiphoton microscopy and 3D multiplexed analysis of tissues; 3D in vitro interaction analyses of immune and tumor cells; preclinical models of adoptive T cell therapy and immunotherapy.

Conditions of employment

Fixed-term contract: 4 years.

Upon commencement of employment we require a certificate of conduct (Verklaring Omtrent het Gedrag, VOG) and there will be, depending on the type of job, a screening based on the provided cv. Radboud university medical center's HR Department will apply for this certificate on your behalf.

Read more about the Radboudumc employment conditions and what our International Office can do for you when moving to the Netherlands.

Employer

Radboudumc

The Department of Cell Biology is a high-level biomedical center studying the molecular and cellular basis of disease, from molecule to man. We offer structured high-profile graduate training programs and the qualified scientific environment for networking and developing your personal skills. You can expect an inspiring, vibrant and technology-driven research environment and group experience.

Research Institutes
At the moment there are more than 1,300 PhD candidates at our medical hospital. This number includes PhD candidates on our pay roll as well as external candidates (those employed somewhere else but researching on our premises).
  • Radboud Institute for Health Sciences: ± 700
  • Radboud Institute for Molecular Life Sciences: ± 400
  • Donders Center for Medical Neurosciences: ± 200
Read what it is like to do a PhD at the Radboud University Medical Center.

Radboudumc
Radboudumc strives to be a leading developer of sustainable, innovative and affordable healthcare to improve the health and wellbeing of people and society in the Netherlands and beyond. This is the core of our mission: To have a significant impact on healthcare. To get a better picture of what this entails, check out our strategy.

Read more about what it means to work at Radboudumc and how you can do your part.

Specifications

  • PhD
  • Natural sciences
  • max. 36 hours per week
  • €2422—€3103 per month
  • University graduate
  • 116203-P599815-1

Employer

Radboud University Medical Center (Radboudumc)

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Location

Geert Grooteplein-Zuid 10, 6525 GA, Nijmegen

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